Tchem APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G

Protein Summary

Description

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9HC16
• B2RDR9
• Q45F02
• Q5TF77
• Q7Z2N1
• Q7Z2N4
• Q9H9H8

Gene Name

• APOBEC3G

Ensembl ID

• ENST00000407997
• ENSP00000385057
• ENSG00000239713

Symbol

• A3G
• ARCD
• ARP9
• ARP-9
• CEM15
• CEM-15
• MDS019
• bK150C2.7
• dJ494G10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological process	0.8
molecular function	0.76
cellular component	0.71
biological term	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Dc->du-editing Enzyme Apobec-3g

Protein / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3g

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3g

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.58   (req: < 5)

Gene RIFs: 359   (req: <= 3)

Antibodies: 574   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.58   (req: >= 5)

Gene RIFs: 359   (req: > 3)

Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0