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Tchem
APOBEC3G
DNA dC->dU-editing enzyme APOBEC-3G

Protein Summary
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407997
  • ENSP00000385057
  • ENSG00000239713

Symbol
  • A3G
  • ARCD
  • ARP9
  • ARP-9
  • CEM15
  • CEM-15
  • MDS019
  • bK150C2.7
  • dJ494G10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.8
molecular function
0.76
cellular component
0.71
biological term
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.48   (req: < 5)
Gene RIFs: 317   (req: <= 3)
Antibodies: 574   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.48   (req: >= 5)
Gene RIFs: 317   (req: > 3)
Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (92)
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.912
Data Source:  STRINGDB
TRIM5
Tbio
Novelty:  0.00289445
Score:  0.897
Data Source:  STRINGDB
BST2
Tbio
Novelty:  0.00254359
Score:  0.854
Data Source:  STRINGDB
APOBEC3F
Tbio
Novelty:  0.00603614
Score:  0.852
Data Source:  STRINGDB
SAMHD1
Tbio
Family:  Enzyme
Novelty:  0.00294595
Score:  0.85
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.82
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.819
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.813
Data Source:  Reactome,STRINGDB
APOBEC4
Tdark
Novelty:  0.13240154
Score:  0.807
Data Source:  STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.798
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
APOBEC3G mediated resistance to HIV-1 infection (R-HSA-180689)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APOBEC3G mediated resistance to HIV-1 infection
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
APOBEC3G mediated resistance to HIV-1 infection
Disease
HIV Infection
Host Interactions of HIV factors
Infectious disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
91.4
lymphocyte count
3
1
3
84
myeloid white cell count
1
1
1
77.6
monocyte count
1
1
1
76.1
leukocyte count
2
3
3
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.4
lymphocyte count
3
84
myeloid white cell count
1
77.6
monocyte count
1
76.1
leukocyte count
3
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
VGNC:6684
449577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
Publication Statistics
PubMed Score 783.48
PubMed score by year
PubTator Score 562.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title