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Tbio
TMEM165
Transmembrane protein 165

Protein Summary
Description
May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation. This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381334
  • ENSP00000370736
  • ENSG00000134851

Symbol
  • TPARL
  • FT27
  • GDT1
  • CDG2K
  • TPARL
  • TMPT27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.76
transcription factor binding site profile
0.63
cellular component
0.62
tissue
0.58


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.17   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.17   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
1
2
95
waist-hip ratio
1
1
1
67.7
sex hormone-binding globulin measurement
1
1
1
61.7
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
95
waist-hip ratio
1
67.7
sex hormone-binding globulin measurement
1
61.7
1
7.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 165
VGNC:723
737422
Macaque
transmembrane protein 165
696262
Mouse
MGI:894407
21982
Rat
RGD:1306983
364137
Dog
transmembrane protein 165
VGNC:47492
475144
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 165
Macaque
transmembrane protein 165
Mouse
Rat
Dog
transmembrane protein 165
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HC07-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (46)
1 – 10 of 46
DDOST
Tchem
Family: Enzyme
Novelty: 0.01797594
Score: 0.737
Data Source: STRINGDB
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
Score: 0.686
Data Source: STRINGDB
SFXN1
Tbio
Novelty: 0.09832047
Score: 0.654
Data Source: STRINGDB
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
Score: 0.64
Data Source: STRINGDB
ATP2C1
Tbio
Family: Transporter
Novelty: 0.00225714
Score: 0.599
Data Source: STRINGDB
ALG2
Tbio
Family: Enzyme
Novelty: 0.03804805
Score: 0.588
Data Source: STRINGDB
DKKL1
Tbio
Novelty: 0.00544618
Score: 0.587
Data Source: STRINGDB
ARL9
Tdark
Family: Enzyme
Novelty: 0.87210932
Score: 0.586
Data Source: STRINGDB
CERS2
Tbio
Family: TF
Novelty: 0.00994797
Score: 0.574
Data Source: STRINGDB
XPR1
Tbio
Novelty: 0.00735578
Score: 0.571
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.17

PubMed score by year
PubTator Score  24.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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