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Tbio
ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

Protein Summary
Description
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of x ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303329
  • ENSP00000307479
  • ENSG00000172379
  • ENST00000527771
  • ENSP00000453792
  • ENST00000533983
  • ENSP00000453651

Symbol
  • BHLHE1
  • KIAA0307
  • WEDAS
  • bHLHe1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
trait
0.75
biological process
0.74
protein domain
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.37   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.37   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
p_int:  0.999998571
p_ni:  0.000001429
Score:  0.565
Data Source:  BioPlex,STRINGDB
TRAF4
Tbio
Novelty:  0.01317133
p_int:  0.999993823
p_ni:  0.000006174
p_wrong:  3e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
SIM2
Tbio
Novelty:  0.00773416
p_int:  0.999862726
p_ni:  8e-9
p_wrong:  0.000137266
Score:  0.878
Data Source:  BioPlex,STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
p_int:  0.999792323
p_ni:  0.00008864
p_wrong:  0.000119038
Score:  0.974
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.993596412
p_ni:  0.000877656
p_wrong:  0.005525932
Score:  0.161
Data Source:  BioPlex,STRINGDB
CLPP
Tchem
Family:  Enzyme
Novelty:  0.00105289
p_int:  0.869188236
p_ni:  0.130810825
p_wrong:  9.39e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.844994716
p_ni:  0.155005284
Score:  0.768
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.804588717
p_ni:  0.195411004
p_wrong:  2.79e-7
Score:  0.194
Data Source:  BioPlex,STRINGDB
AHR
Tchem
Family:  TF
Novelty:  0.37065152
Score:  0.989
Data Source:  Reactome,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.967
Data Source:  STRINGDB
Pathways (15)
Aryl hydrocarbon receptor signalling (R-HSA-8937144)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aryl hydrocarbon receptor signalling
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aryl hydrocarbon receptor signalling
Biological oxidations
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
1
2
59
visceral adipose tissue measurement
1
1
1
44.2
high density lipoprotein cholesterol measurement
1
1
2
39.6
sleep duration
1
1
2
39.6
2
1
0
1.1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
59
visceral adipose tissue measurement
1
44.2
high density lipoprotein cholesterol measurement
2
39.6
sleep duration
2
39.6
0
1.1
14
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107188
11864
Rat
RGD:2154
25243
Dog
aryl hydrocarbon receptor nuclear translocator 2
VGNC:53147
608366
Cow
aryl hydrocarbon receptor nuclear translocator 2
533445
Opossum
aryl hydrocarbon receptor nuclear translocator 2
100013571
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
aryl hydrocarbon receptor nuclear translocator 2
Cow
aryl hydrocarbon receptor nuclear translocator 2
Opossum
aryl hydrocarbon receptor nuclear translocator 2
Publication Statistics
PubMed Score 74.37
PubMed score by year
PubTator Score 22.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title