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Tchem
RXFP1
Relaxin receptor 1

Protein Summary
Description
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307765
  • ENSP00000303248
  • ENSG00000171509
  • ENST00000343542
  • ENSP00000345889
  • ENST00000470033
  • ENSP00000420712
  • ENST00000471616
  • ENSP00000434475

Symbol
  • LGR7
  • LGR7
  • RXFPR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (protein)
0.68
biological term
0.64
cell type or tissue
0.59
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.76   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.76   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
ML290
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (38)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (234)
1 – 10 of 234
CNPY4
Tdark
Novelty: 0.34876479
p_int: 0.999999778
p_ni: 2.22e-7
Data Source: BioPlex
LRRC8D
Tbio
Novelty: 0.19392074
p_int: 0.999974079
p_ni: 0.000025916
p_wrong: 5e-9
Data Source: BioPlex
TMEM237
Tdark
Novelty: 0.52565707
p_int: 0.999972831
p_ni: 0.00000492
p_wrong: 0.000022249
Data Source: BioPlex
ABHD6
Tchem
Family: Enzyme
Novelty: 0.02917188
p_int: 0.99994319
p_ni: 0.000055909
p_wrong: 9.01e-7
Data Source: BioPlex
SLC12A4
Tbio
Family: Transporter
Novelty: 0.01717672
p_int: 0.999857745
p_ni: 0.000142253
p_wrong: 2e-9
Data Source: BioPlex
CGRRF1
Tdark
Novelty: 0.41501976
p_int: 0.999793277
p_ni: 0.000206621
p_wrong: 1.02e-7
Data Source: BioPlex
ABCC5
Tchem
Family: Transporter
Novelty: 0.00755205
p_int: 0.999756599
p_ni: 0.000022015
p_wrong: 0.000221386
Data Source: BioPlex
PPM1L
Tbio
Family: Enzyme
Novelty: 0.17709194
p_int: 0.999511041
p_ni: 0.000288257
p_wrong: 0.000200703
Data Source: BioPlex
DNAJC18
Tdark
p_int: 0.999378223
p_ni: 0.000621777
Data Source: BioPlex
KCNT2
Tchem
Family: IC
Novelty: 0.00289791
p_int: 0.999179563
p_ni: 0.000819571
p_wrong: 8.66e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  185.76

PubMed score by year
PubTator Score  136.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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