Protein Summary
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- ENST00000307765
- ENSP00000303248
- ENSG00000171509
- ENST00000343542
- ENSP00000345889
- ENST00000470033
- ENSP00000420712
- ENST00000471616
- ENSP00000434475
- LGR7
- LGR7
- RXFPR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
ligand (protein) | 0.68 | ||
biological term | 0.64 | ||
cell type or tissue | 0.59 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 222.77 (req: < 5)
Gene RIFs: 62 (req: <= 3)
Antibodies: 334 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 222.77 (req: >= 5)
Gene RIFs: 62 (req: > 3)
Antibodies: 334 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 34
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0