Tbio LGR6 Leucine-rich repeat-containing G-protein coupled receptor 6

Protein Summary

Description

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HBX8
• Q5T509
• Q5T512
• Q6UY15
• Q86VU0
• Q96K69
• Q9BYD7

Gene Name

• LGR6

Ensembl ID

• ENST00000255432
• ENSP00000255432
• ENSG00000133067
• ENST00000367278
• ENSP00000356247
• ENST00000439764
• ENSP00000387869

Symbol

• GPCR
• VTS20631

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein)	0.85
protein domain	0.73
transcription factor binding site profile	0.7
cell type or tissue	0.67
PubMedID	0.65

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Leucine-rich Repeat-containing G-protein Coupled Receptor 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.81   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 320   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.81   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0