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Tbio
ADGRL4
Adhesion G protein-coupled receptor L4

Protein Summary
Description
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370742
  • ENSP00000359778
  • ENSG00000162618

Symbol
  • ELTD1
  • ETL
  • ETL
  • ELTD1
  • KPG_003
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.93
cell type or tissue
0.76
tissue sample
0.72
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.58   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.58   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
79.3
neutrophil count
2
1
2
78.2
eosinophil count
2
1
2
72.6
myeloid white cell count
1
1
1
72.3
hematocrit
2
2
2
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
79.3
neutrophil count
2
78.2
eosinophil count
2
72.6
myeloid white cell count
1
72.3
hematocrit
2
67.7
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
GPCRs, Class B Secretin-like
WikiPathways
GPCRs, Class B Secretin-like
WikiPathways
GPCRs, Class B Secretin-like
WikiPathways
GPCRs, Class B Secretin-like
WikiPathways
GPCRs, Class B Secretin-like
Name
Explore in Pharos
Explore in Source
GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like
Protein-Protein Interactions (28)
1 – 10 of 28
MYCT1
Tbio
Novelty: 0.06576763
Score: 0.773
Data Source: STRINGDB
EMCN
Tbio
Novelty: 0.01537879
Score: 0.688
Data Source: STRINGDB
PHACTR1
Tbio
Family: Enzyme
Novelty: 0.00901547
Score: 0.612
Data Source: STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
Score: 0.594
Data Source: STRINGDB
GSTO1
Tchem
Family: Enzyme
Novelty: 0.00800915
Score: 0.581
Data Source: STRINGDB
NEUROD6
Tbio
Family: TF
Novelty: 0.02073347
Score: 0.564
Data Source: STRINGDB
ZNF366
Tbio
Family: TF
Novelty: 0.1166487
Score: 0.564
Data Source: STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00086809
Score: 0.557
Data Source: STRINGDB
CLEC14A
Tbio
Novelty: 0.03231666
Score: 0.552
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.58

PubMed score by year
PubTator Score  14.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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