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Tchem
LPAR2
Lysophosphatidic acid receptor 2

Protein Summary
Description
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407877
  • ENSP00000384665
  • ENSG00000064547
  • ENST00000542587
  • ENSP00000443256
  • ENST00000586703
  • ENSP00000465280

Symbol
  • EDG4
  • LPA2
  • EDG4
  • LPA2
  • EDG-4
  • LPA-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
biological process
0.69
protein domain
0.58
tissue
0.58
ligand (chemical)
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (40)
Protein-Protein Interactions (407)
HBB
Tbio
Novelty:  0.00049683
p_int:  0.933856684
p_ni:  0.066143316
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.750053522
p_ni:  0.249946478
Score:  0.179
Data Source:  BioPlex,STRINGDB
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
Score:  0.989
Data Source:  STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
Score:  0.988
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.987
Data Source:  STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
Score:  0.972
Data Source:  STRINGDB
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
Score:  0.971
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.966
Data Source:  STRINGDB
P2RY10
Tchem
Family:  GPCR
Novelty:  0.12674578
Score:  0.96
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
6
13
6.9
98.7
total cholesterol measurement
4
4
7
98
low density lipoprotein cholesterol measurement
3
4
4
3.3
97.9
apolipoprotein B measurement
1
3
3
95.6
platelet count
2
2
2
93.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
13
6.9
98.7
total cholesterol measurement
7
98
low density lipoprotein cholesterol measurement
4
3.3
97.9
apolipoprotein B measurement
3
95.6
platelet count
2
93.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidic acid receptor 2
VGNC:2321
455878
Macaque
lysophosphatidic acid receptor 2
719844
Mouse
MGI:1858422
53978
Rat
RGD:1561336
498609
Dog
lysophosphatidic acid receptor 2
VGNC:42743
484802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidic acid receptor 2
Macaque
lysophosphatidic acid receptor 2
Mouse
Rat
Dog
lysophosphatidic acid receptor 2
Publication Statistics
PubMed Score 130.00
PubMed score by year
PubTator Score 111.87
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title