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Tbio
BARX1
Homeobox protein BarH-like 1

Protein Summary
Description
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter. This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253968
  • ENSP00000253968
  • ENSG00000131668
  • ENST00000401724
  • ENSP00000385613
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
gene perturbation
0.7
PubMedID
0.64
cell type or tissue
0.63
biological process
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.35   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.35   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
50.3
1
1
0
1.2
50.3
1
1
0
1.2
50.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
50.3
0
1.2
50.3
0
1.2
50.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BARX homeobox 1
VGNC:4624
745472
Macaque
BARX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:955]
Mouse
MGI:103124
12022
Rat
RGD:1310884
364680
Dog
BARX homeobox 1
VGNC:38382
610486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BARX homeobox 1
Macaque
BARX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:955]
Mouse
Rat
Dog
BARX homeobox 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HBU1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (43)
1 – 10 of 43
BMP4
Tchem
Novelty: 0.00047387
Score: 0.909
Data Source: STRINGDB
FGF8
Tbio
Novelty: 0.00155113
Score: 0.736
Data Source: STRINGDB
LHX8
Tbio
Family: TF
Novelty: 0.01815234
Score: 0.735
Data Source: STRINGDB
LHX6
Tbio
Family: TF
Novelty: 0.01603143
Score: 0.692
Data Source: STRINGDB
PAX9
Tbio
Family: TF
Novelty: 0.00581813
Score: 0.69
Data Source: STRINGDB
TBX22
Tbio
Family: TF
Novelty: 0.00824505
Score: 0.604
Data Source: STRINGDB
OSR2
Tbio
Family: TF
Novelty: 0.02194344
Score: 0.597
Data Source: STRINGDB
SFRP2
Tbio
Novelty: 0.00454703
Score: 0.591
Data Source: STRINGDB
SFRP1
Tchem
Novelty: 0.00285799
Score: 0.578
Data Source: STRINGDB
FOXF1
Tbio
Family: TF
Novelty: 0.00787458
Score: 0.555
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.35

PubMed score by year
PubTator Score  11.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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