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Tbio
TAF9B
Transcription initiation factor TFIID subunit 9B

Protein Summary
Description
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341864
  • ENSP00000339917
  • ENSG00000187325

Symbol
  • TAF9L
  • DN7
  • DN-7
  • TAF9L
  • TAFII31L
  • TFIID-31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.88
microRNA
0.88
biological process
0.81
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
61
potassium measurement
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
61
potassium measurement
1
8.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 9b
VGNC:2905
473679
Macaque
TATA-box binding protein associated factor 9b
706433
Mouse
MGI:3039562
407786
Dog
TATA-box binding protein associated factor 9b
VGNC:47091
480965
Horse
TATA-box binding protein associated factor 9b
VGNC:23857
100072650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 9b
Macaque
TATA-box binding protein associated factor 9b
Mouse
Dog
TATA-box binding protein associated factor 9b
Horse
TATA-box binding protein associated factor 9b
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HBM6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Name
Explore in Pharos
Explore in Source
Deubiquitination
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (132)
1 – 10 of 132
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999911
p_ni:  8.9e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999844
p_ni:  1.56e-7
Data Source:  BioPlex
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999984371
p_ni:  0.000015629
Score:  0.995
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999982063
p_ni:  0.000017888
p_wrong:  4.9e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999979689
p_ni:  0.000020307
p_wrong:  4e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999966083
p_ni:  0.000029668
p_wrong:  0.000004249
Score:  0.945
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.999952836
p_ni:  0.000047164
Score:  0.991
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999922708
p_ni:  0.00007729
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.24

PubMed score by year
PubTator Score  6.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer