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Tbio
SPC25
Kinetochore protein Spc25

Protein Summary
Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282074
  • ENSP00000282074
  • ENSG00000152253
  • ENST00000611144
  • ENSP00000481354
  • ENSG00000277909
  • ENST00000616584
  • ENSP00000483050

Symbol
  • SPBC25
  • AD024
  • SPBC25
  • hSpc25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
interacting protein
0.75
small molecule perturbation
0.71
transcription factor perturbation
0.68
cell line
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (60)
Items per page:
1 – 5 of 60
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
12
6
13
1.3
99.9
fasting blood glucose measurement
12
6
13
1.3
99.9
HbA1c measurement
5
3
5
99.2
HbA1c measurement
5
3
5
99.2
glucose measurement
2
3
3
94.3
Items per page:
1 – 5 of 60
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
13
1.3
99.9
fasting blood glucose measurement
13
1.3
99.9
HbA1c measurement
5
99.2
HbA1c measurement
5
99.2
glucose measurement
3
94.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913692
66442
Rat
RGD:1307811
295661
Dog
SPC25, NDC80 kinetochore complex component
VGNC:46724
488388
Horse
SPC25, NDC80 kinetochore complex component
VGNC:23506
100062715
Cow
SPC25, NDC80 kinetochore complex component
VGNC:35196
505011
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SPC25, NDC80 kinetochore complex component
Horse
SPC25, NDC80 kinetochore complex component
Cow
SPC25, NDC80 kinetochore complex component
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (239)
1 – 10 of 239
SPC24
Tbio
Novelty: 0.03166479
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NSL1
Tbio
Novelty: 0.01396984
p_int: 1
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty: 0.05336903
p_int: 1
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 1
Data Source: BioPlex,Reactome
ZWINT
Tbio
Novelty: 0.02153276
p_int: 0.999999993
p_ni: 7e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
NDC80
Tbio
Novelty: 0.00331814
p_int: 0.999999749
p_ni: 2.51e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EPS15
Tbio
Novelty: 0.00451447
p_int: 0.999999225
p_ni: 7.75e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
MIS12
Tbio
Novelty: 0.05345698
p_int: 0.99999885
p_ni: 0.00000115
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
NUF2
Tbio
Novelty: 0.01069726
p_int: 0.999998771
p_ni: 0.000001229
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FCHO2
Tbio
Novelty: 0.12302279
p_int: 0.999993835
p_ni: 0.000006165
Score: 0.191
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.05

PubMed score by year
PubTator Score  21.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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