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Tbio
NMRAL1
NmrA-like family domain-containing protein 1

Protein Summary
Description
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of inte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283429
  • ENSP00000283429
  • ENSG00000153406
  • ENST00000404295
  • ENSP00000383962
  • ENST00000574425
  • ENSP00000460263
  • ENST00000574733
  • ENSP00000458762
  • ENST00000616587
  • ENSP00000479569
  • ENSG00000274684
  • ENST00000621810
  • ENSP00000478990
  • ENST00000632013
  • ENSP00000488692
  • ENST00000633085
  • ENSP00000488644

Symbol
  • HSCARG
  • HSCARG
  • SDR48A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
tissue sample
0.74
transcription factor binding site profile
0.74
cell line
0.68
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.6   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.6   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (54)
1 – 10 of 54
PHB2
Tbio
Novelty:  0.00458856
p_int:  0.997871234
p_ni:  0.001918725
p_wrong:  0.000210041
Score:  0.691
Data Source:  BioPlex,STRINGDB
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
Score:  0.978
Data Source:  Reactome,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
Score:  0.757
Data Source:  STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
Score:  0.749
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.744
Data Source:  STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
Score:  0.728
Data Source:  STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.705
Data Source:  STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
Score:  0.68
Data Source:  STRINGDB
SNX19
Tbio
Novelty:  0.10613986
Score:  0.68
Data Source:  STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.653
Data Source:  STRINGDB
Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Urea cycle
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
12
22
95.5
waist-hip ratio
4
9
10
85.7
BMI-adjusted hip circumference
3
5
5
77
heel bone mineral density
2
3
5
76.5
waist circumference
1
4
4
60.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
22
95.5
waist-hip ratio
10
85.7
BMI-adjusted hip circumference
5
77
heel bone mineral density
5
76.5
waist circumference
4
60.8
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NmrA like redox sensor 1
VGNC:13749
750296
Macaque
NmrA like redox sensor 1
705343
Mouse
MGI:1915074
67824
Rat
RGD:1311451
287063
Dog
NmrA like redox sensor 1
490026
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NmrA like redox sensor 1
Macaque
NmrA like redox sensor 1
Mouse
Rat
Dog
NmrA like redox sensor 1
Publication Statistics
PubMed Score 18.60
PubMed score by year
PubTator Score 8.03
PubTator score by year