Tbio NMRAL1 NmrA-like family domain-containing protein 1

Protein Summary

Description

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q9HBL8

Gene Name

• NMRAL1

Ensembl ID

• ENST00000283429
• ENSP00000283429
• ENSG00000153406
• ENST00000404295
• ENSP00000383962
• ENST00000574425
• ENSP00000460263
• ENST00000574733
• ENSP00000458762
• ENST00000616587
• ENSP00000479569
• ENSG00000274684
• ENST00000621810
• ENSP00000478990
• ENST00000632013
• ENSP00000488692
• ENST00000633085
• ENSP00000488644

Symbol

• HSCARG
• HSCARG
• SDR48A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
tissue sample	0.74
transcription factor binding site profile	0.74
cell line	0.68
cell type or tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.44   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.44   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0