Tbio AS3MT Arsenite methyltransferase

Protein Summary

Description

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655). AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9HBK9
• A6NP79
• Q0VDK3
• Q0VDK4
• Q5PZ02

Gene Name

• AS3MT

Ensembl ID

• ENST00000369880
• ENSP00000358896
• ENSG00000214435

Symbol

• CYT19
• CYT19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.75
gene perturbation	0.65
cell type or tissue	0.63
transcription factor perturbation	0.61
biological term	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Arsenite Methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Arsenite Methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.32   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.32   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0