Tbio PARVB Beta-parvin

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Beta-parvin

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Beta-parvin

Protein Summary

Description

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9HBI1
• B0QYM8
• B0QYN1
• B2R9X6
• Q5TGJ5
• Q86X93
• Q96PN1
• Q9NSP7
• Q9UGT3
• Q9Y368
• Q9Y3L6
• Q9Y3L7

Gene Name

• PARVB

Ensembl ID

• ENST00000338758
• ENSP00000342492
• ENSG00000188677
• ENST00000404989
• ENSP00000384353
• ENST00000406477
• ENSP00000384515

Symbol

• CGI-56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
interacting protein	0.87
PubMedID	0.84
trait	0.75
transcription factor perturbation	0.74

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.74   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.74   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	1	1	1		52.4
parental longevity	EFO_0007796	1	1	1		44.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	1		52.4
parental longevity	EFO_0007796	1		44.7

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	parvin beta	VGNC:12909	458898
Macaque	parvin beta		715859
Mouse	parvin, beta	MGI:2153063	170736
Rat	parvin, beta	RGD:1311485	362973
Horse	parvin beta	VGNC:21169	100050839

Species	Name	OMA	EggNOG	Inparanoid
Chimp	parvin beta
Macaque	parvin beta
Mouse	parvin, beta
Rat	parvin, beta
Horse	parvin beta

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HBI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (28)

Reactome (4)

KEGG (1)

PathwayCommons (2)

WikiPathways (21)

Cell junction organization (R-HSA-446728)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-extracellular matrix interactions	16 targets	R-HSA-446353
Reactome	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8 targets	R-HSA-446388

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-extracellular matrix interactions	16 targets	R-HSA-446353
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8 targets	R-HSA-446388

Gene Ontology Terms (14)

Functions (1)

Components (7)

Processes (6)

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10

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GO Term	Evidence	Assigned by
actin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

RSU1

Tbio

Novelty: 0.01645054

p_int: 0.999999996

p_ni: 3e-9

p_wrong: 1e-9

Score: 0.968

Data Source: BioPlex,STRINGDB

ILK

Tchem

Family: Kinase

Novelty: 0.00147344

p_int: 0.999999995

p_ni: 2e-9

p_wrong: 3e-9

Score: 0.999

Data Source: BioPlex,STRINGDB

LIMS1

Tbio

Novelty: 0.00648304

p_int: 0.99999998

p_ni: 1e-8

p_wrong: 1e-8

Score: 0.997

Data Source: BioPlex,STRINGDB

PARVA

Tbio

Novelty: 0.02736601

p_int: 0.999999936

p_wrong: 6.4e-8

Score: 0.985

Data Source: BioPlex,STRINGDB

PXN

Tbio

Novelty: 0.00082031

Score: 0.997

Data Source: STRINGDB

ARHGEF6

Tbio

Novelty: 0.02162737

Score: 0.99

Data Source: Reactome,STRINGDB

CDC5L

Tbio

Family: TF

Novelty: 0.00663599

Score: 0.98

Data Source: STRINGDB

LIMS2

Tbio

Novelty: 0.0832739

Score: 0.974

Data Source: STRINGDB

ACTN1

Tbio

Novelty: 0.00654004

Score: 0.921

Data Source: Reactome,STRINGDB

ITGB3

Tclin

Novelty: 0.00067255

Score: 0.84

Data Source: STRINGDB

Publication Statistics

PubMed Score  25.74

PubMed score by year

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PubTator Score  13.6

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Actin-binding
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

monocyte count
parental longevity

MGI Phenotype Find Similar Targets

growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
skeleton phenotype