Protein Summary
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- ENST00000338758
- ENSP00000342492
- ENSG00000188677
- ENST00000404989
- ENSP00000384353
- ENST00000406477
- ENSP00000384515
- CGI-56
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.96 | ||
interacting protein | 0.87 | ||
PubMedID | 0.84 | ||
trait | 0.75 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.51 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.51 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (96)
RSU1
Novelty: 0.01645054
p_int: 0.999999996
p_ni: 3e-9
p_wrong: 1e-9
Score: 0.968
Data Source: BioPlex,STRINGDB
ILK
Family: Kinase
Novelty: 0.00147344
p_int: 0.999999995
p_ni: 2e-9
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
LIMS1
Novelty: 0.00648304
p_int: 0.99999998
p_ni: 1e-8
p_wrong: 1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
PARVA
Novelty: 0.02736601
p_int: 0.999999936
p_wrong: 6.4e-8
Score: 0.985
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (15)
Upstream (14)
Downstream (1)
1 – 5 of 14
Pathways (28)
Reactome (4)
KEGG (1)
PathwayCommons (2)
WikiPathways (21)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-extracellular matrix interactions | ||||
Reactome | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-extracellular matrix interactions | ||||
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (7)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (43)
Items per page:
1 – 5 of 43
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 5 | 4 | 8 | 37.7 | 98.8 | ||||
serum alanine aminotransferase measurement | 8 | 4 | 8 | 6 | 98.8 | ||||
7 | 4 | 1 | 1.7 | 96.9 | |||||
liver fibrosis measurement | 3 | 3 | 9 | 96.7 | |||||
hemoglobin measurement | 4 | 3 | 5 | 95.5 | |||||
Items per page:
1 – 5 of 43
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 8 | 37.7 | 98.8 | ||||
serum alanine aminotransferase measurement | 8 | 6 | 98.8 | ||||
1 | 1.7 | 96.9 | |||||
liver fibrosis measurement | 9 | 96.7 | |||||
hemoglobin measurement | 5 | 95.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | parvin beta | VGNC:12909 | 458898 | |||||
Macaque | parvin beta | 715859 | ||||||
Mouse | MGI:2153063 | 170736 | ||||||
Rat | RGD:1311485 | 362973 | ||||||
Horse | parvin beta | VGNC:21169 | 100050839 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | parvin beta | |||||
Macaque | parvin beta | |||||
Mouse | ||||||
Rat | ||||||
Horse | parvin beta | |||||
Publication Statistics
PubMed Score 26.51
PubMed score by year
PubTator Score 13.60
PubTator score by year
Related Publications
Text Mined References (47)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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