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Tbio
PARVB
Beta-parvin

Protein Summary
Description
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338758
  • ENSP00000342492
  • ENSG00000188677
  • ENST00000404989
  • ENSP00000384353
  • ENST00000406477
  • ENSP00000384515

Symbol
  • CGI-56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
interacting protein
0.87
PubMedID
0.84
trait
0.75
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.51   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.51   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
RSU1
Tbio
Novelty:  0.01645054
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.968
Data Source:  BioPlex,STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LIMS1
Tbio
Novelty:  0.00648304
p_int:  0.99999998
p_ni:  1e-8
p_wrong:  1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
PARVA
Tbio
Novelty:  0.02736601
p_int:  0.999999936
p_wrong:  6.4e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
PXN
Tbio
Novelty:  0.00082031
Score:  0.997
Data Source:  STRINGDB
ARHGEF6
Tbio
Novelty:  0.02162737
Score:  0.99
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
LIMS2
Tbio
Novelty:  0.0832739
Score:  0.974
Data Source:  STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
Score:  0.921
Data Source:  Reactome,STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.84
Data Source:  STRINGDB
Nearest Tclin Targets (15)
Explore Nearest Tclin Targets
1 – 5 of 14
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
ITGB1
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
ITGB7
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
KDR
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
Pathways (28)
Cell junction organization (R-HSA-446728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
5
4
8
37.7
98.8
serum alanine aminotransferase measurement
8
4
8
6
98.8
7
4
1
1.7
96.9
liver fibrosis measurement
3
3
9
96.7
hemoglobin measurement
4
3
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
8
37.7
98.8
serum alanine aminotransferase measurement
8
6
98.8
1
1.7
96.9
liver fibrosis measurement
9
96.7
hemoglobin measurement
5
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
parvin beta
VGNC:12909
458898
Macaque
parvin beta
715859
Mouse
MGI:2153063
170736
Rat
RGD:1311485
362973
Horse
parvin beta
VGNC:21169
100050839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
parvin beta
Macaque
parvin beta
Mouse
Rat
Horse
parvin beta
Publication Statistics
PubMed Score 26.51
PubMed score by year
PubTator Score 13.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title