MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2
Protein Summary
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserve ...more
- ENST00000250896
- ENSP00000250896
- ENSG00000099875
- ENST00000309340
- ENSP00000309485
- ENST00000591601
- ENSP00000467811
- GPRK7
- MNK2
- MNK2
- GPRK7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule | 1 | ||
molecular function | 0.97 | ||
transcription factor binding site profile | 0.79 | ||
kinase perturbation | 0.76 | ||
microRNA | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.02 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 283 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.02 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 283 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 413
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (413)
Protein-Protein Interactions (33)
MAPK14
Family: Kinase
Novelty: 0.00045138
p_int: 0.999535612
p_ni: 1e-9
p_wrong: 0.000464387
Score: 0.683
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (161)
KEGG (3)
PathwayCommons (4)
WikiPathways (154)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | HIF-1 signaling pathway | ||||
KEGG | MAPK signaling pathway | ||||
KEGG | Insulin signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
HIF-1 signaling pathway | ||||
MAPK signaling pathway | ||||
Insulin signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (5)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 2 | 2 | 79.3 | |||||
platelet count | 2 | 2 | 2 | 75.4 | |||||
red blood cell distribution width | 2 | 1 | 2 | 71.9 | |||||
body height | 1 | 1 | 1 | 70 | |||||
body mass index | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 79.3 | |||||
platelet count | 2 | 75.4 | |||||
red blood cell distribution width | 2 | 71.9 | |||||
body height | 1 | 70 | |||||
body mass index | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Data Resources (1)
Chemical Tool
N-(2-methoxyethyl)-4-((6-(pyridin-4-yl)quinazolin-2-yl)amino)benzamide
Details:
- ChEBI: 143119
- Provider: UNC-CH
- Activity: 156 nM
- Selectivity: 0.037
Data:
Order Chemical Tool from:
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MAP kinase interacting serine/threonine kinase 2 | VGNC:13225 | 455561 | |||||
Macaque | MAP kinase interacting serine/threonine kinase 2 | 721436 | ||||||
Mouse | MGI:894279 | 17347 | ||||||
Rat | RGD:1305728 | 299618 | ||||||
Dog | MAP kinase interacting serine/threonine kinase 2 | VGNC:43251 | 612212 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MAP kinase interacting serine/threonine kinase 2 | |||||
Macaque | MAP kinase interacting serine/threonine kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | MAP kinase interacting serine/threonine kinase 2 | |||||
Publication Statistics
PubMed Score 35.02
PubMed score by year
PubTator Score 37.42
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (30)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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