Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserve ...more

Uniprot Accession IDs

Gene Name

MKNK2

Ensembl ID

ENST00000250896
ENSP00000250896
ENSG00000099875
ENST00000309340
ENSP00000309485
ENST00000591601
ENSP00000467811

Symbol

GPRK7
MNK2
MNK2
GPRK7

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule	1

molecular function	0.97

transcription factor binding site profile	0.79

kinase perturbation	0.76

microRNA	0.76

IDG Partner Tools

Dark Kinase Knowledgebase

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.33 (req: < 5)

View Publications

Gene RIFs: 13 (req: <= 3)

View Gene RIFs

Antibodies: 283 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.33 (req: >= 5)

Gene RIFs: 13 (req: > 3)

Antibodies: 283 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 377

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Explore Approved Drugs

IDG Resources

Reagents (1)

Data Resources (1)

Chemical Tool

N-(2-methoxyethyl)-4-((6-(pyridin-4-yl)quinazolin-2-yl)amino)benzamide

Details:

ChEBI: 143119
Provider: UNC-CH
Activity: 156 nM
Selectivity: 0.037

Data:

UNC-BE1-004

Order Chemical Tool from:

https://www.sgc-unc.org/request-idg-tools

Approved Drugs (1)

1 – 1 of 1

apomorphine

Active Ligands (377)

1 – 10 of 377

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		55.4

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		55.4

Beta Count

Odds Ratio

Protein Data Bank (11)

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (161)

KEGG (3)

PathwayCommons (4)

WikiPathways (154)

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	HIF-1 signaling pathway	109 targets	path:hsa04066

KEGG	MAPK signaling pathway	295 targets	path:hsa04010

KEGG	Insulin signaling pathway	137 targets	path:hsa04910

Name	Explore in Pharos	Explore in Source
HIF-1 signaling pathway	109 targets	path:hsa04066

MAPK signaling pathway	295 targets	path:hsa04010

Insulin signaling pathway	137 targets	path:hsa04910

Gene Ontology Terms (18)

Functions (5)

Components (5)

Processes (8)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB

protein serine/threonine kinase activity	Inferred from Direct Assay (IDA)	UniProtKB

calcium-dependent protein serine/threonine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

calmodulin-dependent protein kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (33)

1 – 10 of 33

See Interactions on String-DB

MAPK14

Tchem

Family: Kinase

Novelty: 0.00045138

p_int: 0.999535612

p_ni: 1e-9

p_wrong: 0.000464387

Score: 0.683

Data Source: BioPlex,STRINGDB

MAPK1

Tchem

Family: Kinase

Novelty: 0.00061058

Score: 0.964

Data Source: STRINGDB

MAPK3

Tchem

Family: Kinase

Novelty: 0.00012969

Score: 0.942

Data Source: STRINGDB

EIF4E

Tchem

Novelty: 0.00072182

Score: 0.884

Data Source: STRINGDB

EIF4E1B

Tdark

Novelty: 0.28023341

Score: 0.827

Data Source: STRINGDB

EIF4E2

Tbio

Novelty: 0.0490219

Score: 0.822

Data Source: STRINGDB

MKNK1

Tchem

Family: Kinase

Novelty: 0.01445137

Score: 0.809

Data Source: STRINGDB

ATF4

Tbio

Family: TF

Novelty: 0.00253408

Score: 0.808

Data Source: STRINGDB

SRPK1

Tchem

Family: Kinase

Novelty: 0.01066655

Score: 0.678

Data Source: STRINGDB

EIF4G1

Tbio

Novelty: 0.00170995

Score: 0.665

Data Source: STRINGDB

Publication Statistics

PubMed Score 32.33

PubMed score by year

PubTator Score 37.42

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword


3D-structure

Alternative splicing

Apoptosis

ATP-binding

Complete proteome

Cytoplasm

Kinase

Magnesium

Metal-binding

Nucleotide-binding

GWAS Trait