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Tchem
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

Protein Classes
Protein Summary
Description
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250896
  • ENSP00000250896
  • ENSG00000099875
  • ENST00000309340
  • ENSP00000309485
  • ENST00000591601
  • ENSP00000467811

Symbol
  • GPRK7
  • MNK2
  • MNK2
  • GPRK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
1
molecular function
0.97
transcription factor binding site profile
0.79
kinase perturbation
0.76
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.33   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.33   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 377
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
apomorphine
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
55.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
55.4
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (161)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
HIF-1 signaling pathway
KEGG
MAPK signaling pathway
KEGG
Insulin signaling pathway
Name
Explore in Pharos
Explore in Source
HIF-1 signaling pathway
MAPK signaling pathway
Insulin signaling pathway
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999535612
p_ni: 1e-9
p_wrong: 0.000464387
Score: 0.683
Data Source: BioPlex,STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.964
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.942
Data Source: STRINGDB
EIF4E
Tchem
Novelty: 0.00072182
Score: 0.884
Data Source: STRINGDB
EIF4E1B
Tdark
Novelty: 0.28023341
Score: 0.827
Data Source: STRINGDB
EIF4E2
Tbio
Novelty: 0.0490219
Score: 0.822
Data Source: STRINGDB
MKNK1
Tchem
Family: Kinase
Novelty: 0.01445137
Score: 0.809
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.808
Data Source: STRINGDB
SRPK1
Tchem
Family: Kinase
Novelty: 0.01066655
Score: 0.678
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.665
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.33

PubMed score by year
PubTator Score  37.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer