Protein Summary
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.
- ENST00000381249
- ENSP00000370648
- ENSG00000240857
- PAN2
- SDR7C4
- PAN2
- SDR7C4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.96 | ||
transcription factor perturbation | 0.8 | ||
kinase perturbation | 0.76 | ||
tissue sample | 0.72 | ||
pathway | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.34 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.34 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (34)
ARL8A
Family: Enzyme
Novelty: 0.12499089
p_int: 0.999994152
p_ni: 0.000005848
Data Source: BioPlex
C3AR1
Family: GPCR
Novelty: 0.00527301
p_int: 0.999976073
p_ni: 0.000023927
Data Source: BioPlex
BRINP2
Novelty: 0.5101917
p_int: 0.999944755
p_ni: 0.000055244
p_wrong: 1e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
TACR1
Family: GPCR
Novelty: 0.00062762
p_int: 0.999712521
p_ni: 0.000239164
p_wrong: 0.000048315
Data Source: BioPlex
RNF170
Family: Enzyme
Novelty: 0.1117879
p_int: 0.999572124
p_ni: 0.000354571
p_wrong: 0.000073305
Data Source: BioPlex
TSPAN5
Novelty: 0.08879443
p_int: 0.999422328
p_ni: 0.00057742
p_wrong: 2.52e-7
Data Source: BioPlex
TSPAN3
Novelty: 0.06362133
p_int: 0.998135042
p_ni: 0.000721267
p_wrong: 0.00114369
Score: 0.227
Data Source: BioPlex,STRINGDB
PCDHA8
Novelty: 0.57189179
p_int: 0.9952214
p_ni: 0.004018782
p_wrong: 0.000759818
Data Source: BioPlex
TGFA
Novelty: 0.00216159
p_int: 0.993268043
p_ni: 0.006261569
p_wrong: 0.000470388
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | RA biosynthesis pathway | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Nuclear Receptors | ||||
Reactome | Signaling by Retinoic Acid | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RA biosynthesis pathway | ||||
Signal Transduction | ||||
Signaling by Nuclear Receptors | ||||
Signaling by Retinoic Acid | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 5 | 6 | 5 | 6.1 | 89 | ||||
2 | 2 | 2 | 38.7 | ||||||
urate measurement | 2 | 2 | 2 | 34.8 | |||||
vital capacity | 1 | 1 | 1 | 15.7 | |||||
forced expiratory volume | 1 | 1 | 1 | 15.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 5 | 6.1 | 89 | ||||
2 | 38.7 | ||||||
urate measurement | 2 | 34.8 | |||||
vital capacity | 1 | 15.7 | |||||
forced expiratory volume | 1 | 15.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1920402 | 105014 | ||||||
Rat | RGD:1565196 | 500629 | ||||||
Dog | retinol dehydrogenase 14 | VGNC:49225 | 100856223 | |||||
Cow | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | 505949 | ||||||
Opossum | retinol dehydrogenase 14 | 103093572 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | retinol dehydrogenase 14 | |||||
Cow | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | |||||
Opossum | retinol dehydrogenase 14 | |||||
Publication Statistics
PubMed Score 2.34
PubMed score by year
PubTator Score 1.58
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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