Tdark RDH14 Retinol dehydrogenase 14

Protein Summary

Description

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.

Uniprot Accession IDs

• Q9HBH5

Gene Name

• RDH14

Ensembl ID

• ENST00000381249
• ENSP00000370648
• ENSG00000240857

Symbol

• PAN2
• SDR7C4
• PAN2
• SDR7C4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
transcription factor perturbation	0.8
kinase perturbation	0.76
tissue sample	0.72
pathway	0.65

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Retinol Dehydrogenase 14

Protein / Oxidoreductase / Dehydrogenase / Retinol Dehydrogenase 14

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Retinol Dehydrogenase 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0