Tbio LY9 T-lymphocyte surface antigen Ly-9

Protein Summary

Description

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9HBG7
• A8K7N3
• Q14775
• Q5VYI3
• Q6P2J4
• Q9H4N5
• Q9NQ24

Gene Name

• LY9

Ensembl ID

• ENST00000263285
• ENSP00000263285
• ENSG00000122224
• ENST00000368037
• ENSP00000357016

Symbol

• hly9
• mLY9
• CD229
• SLAMF3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.73
tissue sample	0.73
co-expressed gene	0.72
protein domain	0.58
microRNA	0.57

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / T-lymphocyte Surface Antigen Ly-9

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / T-lymphocyte Surface Antigen Ly-9

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / T-lymphocyte Surface Antigen Ly-9

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / T-lymphocyte Surface Antigen Ly-9

Protein / Cell Adhesion Molecule / T-lymphocyte Surface Antigen Ly-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.68   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 583   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.68   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 583   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0