Tbio IFT122 Intraflagellar transport protein 122 homolog

Protein Summary

Description

Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9HBG6
• B3KW53
• B4DEY9
• B4DPW7
• E7EQF4
• E9PDG2
• E9PDX2
• G3XAB1
• H7C3C0
• Q53G36
• Q8TC06
• Q9BTB9
• Q9BTY4
• Q9HAT9
• Q9HBG5
• Q9NV68
• Q9UF80

Gene Name

• IFT122

Ensembl ID

• ENST00000296266
• ENSP00000296266
• ENSG00000163913
• ENST00000347300
• ENSP00000323973
• ENST00000348417
• ENSP00000324005
• ENST00000349441
• ENSP00000324165
• ENST00000431818
• ENSP00000410946
• ENST00000440957
• ENSP00000401569
• ENST00000504021
• ENSP00000422179
• ENST00000507564
• ENSP00000425536

Symbol

• SPG
• WDR10
• WDR140
• CED
• SPG
• CED1
• WDR10
• WDR10p
• WDR140

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.81
transcription factor binding site profile	0.79
histone modification site profile	0.7
cell type or tissue	0.69
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.48   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.48   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0