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Tbio
IFT122
Intraflagellar transport protein 122 homolog

Protein Summary
Description
Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296266
  • ENSP00000296266
  • ENSG00000163913
  • ENST00000347300
  • ENSP00000323973
  • ENST00000348417
  • ENSP00000324005
  • ENST00000349441
  • ENSP00000324165
  • ENST00000431818
  • ENSP00000410946
  • ENST00000440957
  • ENSP00000401569
  • ENST00000504021
  • ENSP00000422179
  • ENST00000507564
  • ENSP00000425536

Symbol
  • SPG
  • WDR10
  • WDR140
  • CED
  • SPG
  • CED1
  • WDR10
  • WDR10p
  • WDR140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.81
transcription factor binding site profile
0.79
histone modification site profile
0.7
cell type or tissue
0.69
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
IFT43
Tbio
Novelty:  0.00478274
p_int:  0.999999999
p_ni:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
WDR35
Tbio
Novelty:  0.02958717
p_int:  0.999988196
p_ni:  0.000011798
p_wrong:  6e-9
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
WDR19
Tbio
Novelty:  0.037197
p_int:  0.999986998
p_ni:  0.000013002
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
C11orf74
Tbio
Novelty:  0.17027595
p_int:  0.999984391
p_ni:  0.000015609
Score:  0.884
Data Source:  BioPlex,STRINGDB
IFT140
Tbio
Novelty:  0.02872897
p_int:  0.999955656
p_ni:  0.000044344
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999942805
p_ni:  0.000057195
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.993319288
p_ni:  0.006680712
Score:  0.537
Data Source:  BioPlex,STRINGDB
TULP2
Tbio
Family:  TF
Novelty:  0.20144336
p_int:  0.992551495
p_ni:  0.007448505
Score:  0.734
Data Source:  BioPlex,STRINGDB
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.932616522
p_ni:  0.067383478
Data Source:  BioPlex
DEF8
Tbio
Novelty:  0.21146806
p_int:  0.929174571
p_ni:  0.070825429
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
25
64
98.7
BMI-adjusted hip circumference
5
23
44
96.9
BMI-adjusted waist circumference
2
13
18
85
type 2 diabetes mellitus
3
2
2
1.1
58.5
brain measurement
1
1
0
7.6
51
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
64
98.7
BMI-adjusted hip circumference
44
96.9
BMI-adjusted waist circumference
18
85
type 2 diabetes mellitus
2
1.1
58.5
brain measurement
0
7.6
51
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 122
VGNC:11414
460684
Macaque
intraflagellar transport 122
703060
Mouse
MGI:1932386
81896
Rat
RGD:1311302
312651
Dog
intraflagellar transport 122
VGNC:41883
476528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 122
Macaque
intraflagellar transport 122
Mouse
Rat
Dog
intraflagellar transport 122
Publication Statistics
PubMed Score 52.48
PubMed score by year
PubTator Score 29.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title