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Tbio
ATP6V0A4
V-type proton ATPase 116 kDa subunit a isoform 4

Protein Summary
Description
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310018
  • ENSP00000308122
  • ENSG00000105929
  • ENST00000353492
  • ENSP00000253856
  • ENST00000393054
  • ENSP00000376774
  • ENST00000645515
  • ENSP00000496421

Symbol
  • ATP6N1B
  • ATP6N2
  • A4
  • STV1
  • VPH1
  • VPP2
  • RTA1C
  • RTADR
  • ATP6N2
  • RDRTA2
  • ATP6N1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.94
trait
0.75
gene perturbation
0.7
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.65   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.65   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
Score:  0.997
Data Source:  STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
Score:  0.993
Data Source:  STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
Score:  0.992
Data Source:  STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.992
Data Source:  STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
Score:  0.991
Data Source:  STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.991
Data Source:  STRINGDB
ATP6V0B
Tbio
Family:  Enzyme
Novelty:  0.06595421
Score:  0.99
Data Source:  STRINGDB
ATP6V1A
Tbio
Family:  Enzyme
Novelty:  0.00921474
Score:  0.99
Data Source:  STRINGDB
ATP6V1B2
Tchem
Family:  Enzyme
Novelty:  0.01767911
Score:  0.989
Data Source:  STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
2
39.6
sleep duration
1
1
2
39.6
age-related hearing impairment
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
39.6
sleep duration
2
39.6
age-related hearing impairment
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit a4
VGNC:8672
463765
Macaque
ATPase H+ transporting V0 subunit a4
715492
Mouse
MGI:2153480
140494
Rat
RGD:1305055
296981
Dog
ATPase H+ transporting V0 subunit a4
VGNC:38270
482779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit a4
Macaque
ATPase H+ transporting V0 subunit a4
Mouse
Rat
Dog
ATPase H+ transporting V0 subunit a4
Publication Statistics
PubMed Score 71.65
PubMed score by year
PubTator Score 29.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title