ATP6V0A4
V-type proton ATPase 116 kDa subunit a isoform 4
Protein Summary
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene ...more
- ENST00000310018
- ENSP00000308122
- ENSG00000105929
- ENST00000353492
- ENSP00000253856
- ENST00000393054
- ENSP00000376774
- ENST00000645515
- ENSP00000496421
- ATP6N1B
- ATP6N2
- A4
- STV1
- VPH1
- VPP2
- RTA1C
- RTADR
- ATP6N2
- RDRTA2
- ATP6N1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
biological process | 0.94 | ||
trait | 0.75 | ||
gene perturbation | 0.7 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.65 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 113 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.65 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 113 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
Nearest Tclin Targets
Pathways (22)
Reactome (11)
KEGG (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Insulin receptor recycling | ||||
Reactome | Ion channel transport | ||||
Reactome | Iron uptake and transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Insulin receptor recycling | ||||
Ion channel transport | ||||
Iron uptake and transport | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (2)
Components (12)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 1 | 2 | 39.6 | |||||
sleep duration | 1 | 1 | 2 | 39.6 | |||||
age-related hearing impairment | 1 | 1 | 0 | 5.6 | 21.5 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 2 | 39.6 | |||||
sleep duration | 2 | 39.6 | |||||
age-related hearing impairment | 0 | 5.6 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATPase H+ transporting V0 subunit a4 | VGNC:8672 | 463765 | |||||
Macaque | ATPase H+ transporting V0 subunit a4 | 715492 | ||||||
Mouse | MGI:2153480 | 140494 | ||||||
Rat | RGD:1305055 | 296981 | ||||||
Dog | ATPase H+ transporting V0 subunit a4 | VGNC:38270 | 482779 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATPase H+ transporting V0 subunit a4 | |||||
Macaque | ATPase H+ transporting V0 subunit a4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATPase H+ transporting V0 subunit a4 | |||||
Publication Statistics
PubMed Score 71.65
PubMed score by year
PubTator Score 29.29
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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