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Tbio
ZFYVE1
Zinc finger FYVE domain-containing protein 1

Protein Summary
Description
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318876
  • ENSP00000326921
  • ENSG00000165861
  • ENST00000394207
  • ENSP00000377757
  • ENST00000555072
  • ENSP00000452232
  • ENST00000556143
  • ENSP00000450742

Symbol
  • DFCP1
  • KIAA1589
  • TAFF1
  • ZNFN2A1
  • SR3
  • DFCP1
  • TAFF1
  • ZNFN2A1
  • PPP1R172
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.86
transcription factor
0.8
cell type or tissue
0.74
protein domain
0.73
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.24   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.24   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
76.7
intelligence
1
1
0
5.7
63.6
red blood cell distribution width
1
1
1
48.8
low density lipoprotein cholesterol measurement
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
76.7
intelligence
0
5.7
63.6
red blood cell distribution width
1
48.8
low density lipoprotein cholesterol measurement
1
20.5
Protein-Protein Interactions (90)
1 – 10 of 90
MID1
Tbio
Family: Enzyme
Novelty: 0.02400169
p_int: 0.999854238
p_ni: 0.000145629
p_wrong: 1.33e-7
Score: 0.215
Data Source: BioPlex,STRINGDB
KCTD6
Tbio
Novelty: 0.43478298
p_int: 0.998996994
p_ni: 0.000797059
p_wrong: 0.000205947
Score: 0.332
Data Source: BioPlex,STRINGDB
LIMD1
Tbio
Novelty: 0.04868333
p_int: 0.992133159
p_ni: 0.007863586
p_wrong: 0.000003255
Score: 0.209
Data Source: BioPlex,STRINGDB
LONRF2
Tdark
Family: Enzyme
Novelty: 1.01811251
p_int: 0.886325613
p_ni: 0.002660945
p_wrong: 0.111013442
Score: 0.218
Data Source: BioPlex,STRINGDB
WIPI2
Tbio
Novelty: 0.02685992
Score: 0.825
Data Source: STRINGDB
STAM2
Tbio
Novelty: 0.04440236
Score: 0.822
Data Source: STRINGDB
STAM
Tbio
Novelty: 0.0332731
Score: 0.822
Data Source: STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
Score: 0.784
Data Source: STRINGDB
ATG14
Tbio
Novelty: 0.00914791
Score: 0.78
Data Source: STRINGDB
WIPI1
Tbio
Novelty: 0.01070744
Score: 0.756
Data Source: STRINGDB
Publication Statistics
PubMed Score  266.24

PubMed score by year
PubTator Score  46.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer