Tbio IL21R Interleukin-21 receptor

Protein Summary

Description

This is a receptor for interleukin-21. The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9HBE5
• A8K9E8
• D3DWF7
• Q96HZ1
• Q9HB91
• IL-21 receptor

Gene Name

• IL21R

Ensembl ID

• ENST00000337929
• ENSP00000338010
• ENSG00000103522
• ENST00000395754
• ENSP00000379103
• ENST00000564089
• ENSP00000456707

Symbol

• NILR
• NILR
• CD360
• IMD56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.7
trait	0.61
cell line	0.57
microRNA	0.56
transcription factor	0.54

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-21 Receptor

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-21 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.12   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.12   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0