IL21R
Interleukin-21 receptor
Protein Summary
This is a receptor for interleukin-21. The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
- ENST00000337929
- ENSP00000338010
- ENSG00000103522
- ENST00000395754
- ENSP00000379103
- ENST00000564089
- ENSP00000456707
- NILR
- NILR
- CD360
- IMD56
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.7 | ||
trait | 0.61 | ||
cell line | 0.57 | ||
microRNA | 0.56 | ||
transcription factor | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 81.29 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 433 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 81.29 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 433 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (159)
Nearest Tclin Targets (11)
Upstream (6)
Downstream (5)
1 – 5 of 6
Pathways (10)
Reactome (5)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-2 family signaling | ||||
Reactome | Interleukin-21 signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-2 family signaling | ||||
Interleukin-21 signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 4 | 5 | 96.4 | |||||
5 | 8 | 0 | 1.1 | 92.1 | |||||
eosinophil percentage of leukocytes | 2 | 3 | 3 | 91.8 | |||||
childhood onset asthma | 2 | 1 | 0 | 1.1 | 77.9 | ||||
C-reactive protein measurement | 2 | 1 | 2 | 70.5 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 5 | 96.4 | |||||
0 | 1.1 | 92.1 | |||||
eosinophil percentage of leukocytes | 3 | 91.8 | |||||
childhood onset asthma | 0 | 1.1 | 77.9 | ||||
C-reactive protein measurement | 2 | 70.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | interleukin 21 receptor | 705759 | ||||||
Mouse | MGI:1890475 | 60504 | ||||||
Rat | RGD:1304950 | 308977 | ||||||
Dog | interleukin 21 receptor | VGNC:41968 | 608011 | |||||
Horse | interleukin 21 receptor | VGNC:19017 | 100066814 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | interleukin 21 receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 21 receptor | |||||
Horse | interleukin 21 receptor | |||||
Publication Statistics
PubMed Score 81.29
PubMed score by year
PubTator Score 85.31
PubTator score by year
Related Publications
Text Mined References (54)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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