Tbio IL21R Interleukin-21 receptor

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-21 Receptor

Protein Summary

Description

This is a receptor for interleukin-21. The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9HBE5
• A8K9E8
• D3DWF7
• Q96HZ1
• Q9HB91
• IL-21 receptor

Gene Name

• IL21R

Ensembl ID

• ENST00000337929
• ENSP00000338010
• ENSG00000103522
• ENST00000395754
• ENSP00000379103
• ENST00000564089
• ENSP00000456707

Symbol

• NILR
• NILR
• CD360
• IMD56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.7
trait	0.61
cell line	0.57
microRNA	0.56
transcription factor	0.54

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.32   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.32   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (10)

Reactome (5)

KEGG (4)

WikiPathways (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-2 family signaling	44 targets	R-HSA-451927
Reactome	Interleukin-21 signaling	10 targets	R-HSA-9020958
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-2 family signaling	44 targets	R-HSA-451927
Interleukin-21 signaling	10 targets	R-HSA-9020958
Signaling by Interleukins	619 targets	R-HSA-449147

Gene Ontology Terms (7)

Functions (3)

Components (2)

Processes (2)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytokine receptor activity	Inferred from Direct Assay (IDA)	MGI
transmembrane signaling receptor activity	Inferred from Direct Assay (IDA)	MGI
interleukin-21 receptor activity	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (159)

Explore Interacting Targets

1 – 10 of 159

• See Interactions on String-DB

IL21

Tbio

Novelty: 0.00383812

Score: 0.998

Data Source: Reactome,STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00013496

Score: 0.972

Data Source: Reactome,STRINGDB

JAK1

Tclin

Family: Kinase

Novelty: 0.00136831

Score: 0.963

Data Source: Reactome,STRINGDB

IL2RG

Tclin

Novelty: 0.00155443

Score: 0.959

Data Source: Reactome,STRINGDB

JAK3

Tclin

Family: Kinase

Novelty: 0.00219647

Score: 0.957

Data Source: Reactome,STRINGDB

STAT1

Tchem

Family: TF

Novelty: 0.00041067

Score: 0.948

Data Source: Reactome,STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00091229

Score: 0.947

Data Source: STRINGDB

STAT4

Tbio

Family: TF

Novelty: 0.00296176

Score: 0.946

Data Source: Reactome,STRINGDB

STAT5B

Tchem

Family: TF

Novelty: 0.00091216

Score: 0.945

Data Source: STRINGDB

IL15

Tbio

Novelty: 0.00081119

Score: 0.846

Data Source: STRINGDB

Publication Statistics

PubMed Score  87.32

PubMed score by year

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PubTator Score  85.31

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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MGI Phenotype Find Similar Targets

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