Tbio IL21 Interleukin-21

Protein Summary

Description

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9HBE4
• A5J0L4
• IL-21

Gene Name

• IL21

Ensembl ID

• ENST00000264497
• ENSP00000264497
• ENSG00000138684
• ENST00000611104
• ENSP00000477555

Symbol

• Za11
• IL-21
• CVID11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
biological process	0.97
tissue	0.8
gene perturbation	0.59
disease	0.52

Protein Classes

DTO Classes

Interleukin-21 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.85   (req: < 5)

Gene RIFs: 358   (req: <= 3)

Antibodies: 770   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.85   (req: >= 5)

Gene RIFs: 358   (req: > 3)

Antibodies: 770   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0