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Tbio
IL21
Interleukin-21

Protein Classes
Protein Summary
Description
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264497
  • ENSP00000264497
  • ENSG00000138684
  • ENST00000611104
  • ENSP00000477555

Symbol
  • Za11
  • IL-21
  • CVID11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
biological process
0.97
tissue
0.8
gene perturbation
0.59
disease
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.71   (req: < 5)
Gene RIFs: 287   (req: <= 3)
Antibodies: 770   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.71   (req: >= 5)
Gene RIFs: 287   (req: > 3)
Antibodies: 770   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-2 family signaling
Reactome
Interleukin-21 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-2 family signaling
Interleukin-21 signaling
Signaling by Interleukins
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (189)
1 – 10 of 189
ALDH1A1
Tchem
Family: Enzyme
Novelty: 0.00144812
p_int: 0.846032248
p_ni: 0.128541769
p_wrong: 0.025425983
Score: 0.692
Data Source: BioPlex,STRINGDB
IL21R
Tbio
Novelty: 0.0125523
Score: 0.998
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.979
Data Source: Reactome,STRINGDB
IL2RG
Tclin
Novelty: 0.00155443
Score: 0.958
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.00041067
Score: 0.956
Data Source: Reactome,STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00296176
Score: 0.954
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00091229
Score: 0.949
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00091216
Score: 0.945
Data Source: STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00219647
Score: 0.94
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00136831
Score: 0.933
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  374.71

PubMed score by year
PubTator Score  592.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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