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Tbio
PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

Protein Summary
Description
Transcriptional repressor. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spli ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215919
  • ENSP00000215919
  • ENSG00000100105
  • ENST00000266269
  • ENSP00000266269
  • ENST00000351933
  • ENSP00000337520
  • ENST00000405309
  • ENSP00000384173

Symbol
  • PATZ
  • RIAZ
  • ZBTB19
  • ZNF278
  • ZSG
  • ZSG
  • MAZR
  • PATZ
  • RIAZ
  • ZBTB19
  • ZNF278
  • dJ400N23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.96
virus perturbation
0.95
virus
0.89
transcription factor
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.87   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.87   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
53.2
reticulocyte count
3
1
3
39.5
reticulocyte measurement
1
1
1
31.7
red blood cell distribution width
1
1
1
29.8
body height
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
53.2
reticulocyte count
3
39.5
reticulocyte measurement
1
31.7
red blood cell distribution width
1
29.8
body height
1
8.3
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Coregulation of Androgen receptor activity
PathwayCommons: netpath
AndrogenReceptor
Name
Explore in Pharos
Explore in Source
Coregulation of Androgen receptor activity
AndrogenReceptor
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (58)
1 – 10 of 58
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999975481
p_ni: 0.000024519
Data Source: BioPlex
ZBTB24
Tbio
Family: TF
Novelty: 0.041401
p_int: 0.999283759
p_ni: 0.000716229
p_wrong: 1.1e-8
Data Source: BioPlex
OMD
Tbio
Novelty: 0.01992089
p_int: 0.973033422
p_ni: 0.026966569
p_wrong: 9e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.958904503
p_ni: 0.041095375
p_wrong: 1.22e-7
Data Source: BioPlex
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.93730538
p_ni: 0.062694619
p_wrong: 1e-9
Data Source: BioPlex
FGF3
Tbio
Novelty: 0.00474087
p_int: 0.925604362
p_ni: 0.074395524
p_wrong: 1.14e-7
Data Source: BioPlex
CLEC11A
Tbio
Novelty: 0.03060601
p_int: 0.890038589
p_ni: 0.109961411
Score: 0.187
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.850431826
p_ni: 0.149568174
Score: 0.16
Data Source: BioPlex,STRINGDB
ZNF169
Tdark
Family: TF
Novelty: 1.09432767
p_int: 0.82326081
p_ni: 0.17673886
p_wrong: 3.29e-7
Data Source: BioPlex
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.81025856
p_ni: 0.18974144
Score: 0.155
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  59.87

PubMed score by year
PubTator Score  38.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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