Protein Summary
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expres ...more
- ENST00000357244
- ENSP00000349783
- ENSG00000056586
- ENST00000373670
- ENSP00000362774
- ENST00000423239
- ENSP00000411767
- ENST00000471874
- ENSP00000474148
- ENST00000498479
- ENSP00000474709
- MNAB
- RNF164
- MNAB
- RNF164
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
transcription factor perturbation | 0.91 | ||
biological process | 0.73 | ||
kinase perturbation | 0.71 | ||
cell line | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.86 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 52 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.86 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 52 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
KLHL6
Novelty: 0.1573847
p_int: 0.999986924
p_ni: 0.000013063
p_wrong: 1.3e-8
Score: 0.458
Data Source: BioPlex,STRINGDB
PFDN4
Novelty: 0.02133605
p_int: 0.999849062
p_ni: 0.000085928
p_wrong: 0.00006501
Score: 0.233
Data Source: BioPlex,STRINGDB
CYP19A1
Family: Enzyme
Novelty: 0.0003187
p_int: 0.999044367
p_ni: 0.000955628
p_wrong: 5e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
UniProt (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
UniProt | Protein modification; protein ubiquitination. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein modification; protein ubiquitination. | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (8)
Components (4)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
birth weight | 2 | 2 | 2 | 69.9 | |||||
insomnia measurement | 1 | 2 | 0 | 1.1 | 57.1 | ||||
1 | 1 | 1 | 54.4 | ||||||
vitamin D measurement | 2 | 2 | 2 | 45.6 | |||||
wellbeing measurement | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
birth weight | 2 | 69.9 | |||||
insomnia measurement | 0 | 1.1 | 57.1 | ||||
1 | 54.4 | ||||||
vitamin D measurement | 2 | 45.6 | |||||
wellbeing measurement | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ring finger and CCCH-type domains 2 | VGNC:13952 | 464715 | |||||
Macaque | ring finger and CCCH-type domains 2 | 695984 | ||||||
Mouse | MGI:2442789 | 319817 | ||||||
Rat | RGD:1304833 | 311909 | ||||||
Horse | ring finger and CCCH-type domains 2 | VGNC:22261 | 100067476 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ring finger and CCCH-type domains 2 | |||||
Macaque | ring finger and CCCH-type domains 2 | |||||
Mouse | ||||||
Rat | ||||||
Horse | ring finger and CCCH-type domains 2 | |||||
Publication Statistics
PubMed Score 7.86
PubMed score by year
PubTator Score 4.62
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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