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Tbio
RC3H2
Roquin-2

Protein Summary
Description
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357244
  • ENSP00000349783
  • ENSG00000056586
  • ENST00000373670
  • ENSP00000362774
  • ENST00000423239
  • ENSP00000411767
  • ENST00000471874
  • ENSP00000474148
  • ENST00000498479
  • ENSP00000474709

Symbol
  • MNAB
  • RNF164
  • MNAB
  • RNF164
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor perturbation
0.91
biological process
0.73
kinase perturbation
0.71
cell line
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.86   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.86   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
KLHL6
Tbio
Novelty:  0.1573847
p_int:  0.999986924
p_ni:  0.000013063
p_wrong:  1.3e-8
Score:  0.458
Data Source:  BioPlex,STRINGDB
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999849062
p_ni:  0.000085928
p_wrong:  0.00006501
Score:  0.233
Data Source:  BioPlex,STRINGDB
CYP19A1
Tclin
Family:  Enzyme
Novelty:  0.0003187
p_int:  0.999044367
p_ni:  0.000955628
p_wrong:  5e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.926370882
p_ni:  0.073629118
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
Score:  0.813
Data Source:  STRINGDB
PHIP
Tbio
Family:  Epigenetic
Novelty:  0.02496083
Score:  0.721
Data Source:  STRINGDB
CEP350
Tbio
Novelty:  0.09063779
Score:  0.71
Data Source:  STRINGDB
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
Score:  0.688
Data Source:  STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
Score:  0.682
Data Source:  STRINGDB
LTN1
Tbio
Family:  Enzyme
Novelty:  0.02604262
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
2
2
69.9
insomnia measurement
1
2
0
1.1
57.1
1
1
1
54.4
vitamin D measurement
2
2
2
45.6
wellbeing measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
69.9
insomnia measurement
0
1.1
57.1
1
54.4
vitamin D measurement
2
45.6
wellbeing measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger and CCCH-type domains 2
VGNC:13952
464715
Macaque
ring finger and CCCH-type domains 2
695984
Mouse
MGI:2442789
319817
Rat
RGD:1304833
311909
Horse
ring finger and CCCH-type domains 2
VGNC:22261
100067476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger and CCCH-type domains 2
Macaque
ring finger and CCCH-type domains 2
Mouse
Rat
Horse
ring finger and CCCH-type domains 2
Publication Statistics
PubMed Score 7.86
PubMed score by year
PubTator Score 4.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title