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Tchem
TRPV4
Transient receptor potential cation channel subfamily V member 4

Protein Classes
Protein Summary
Description
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecano ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261740
  • ENSP00000261740
  • ENSG00000111199
  • ENST00000418703
  • ENSP00000406191
  • ENST00000536838
  • ENSP00000444336
  • ENST00000537083
  • ENSP00000442738
  • ENST00000541794
  • ENSP00000442167
  • ENST00000544971
  • ENSP00000443611

Symbol
  • VRL2
  • VROAC
  • SMAL
  • VRL2
  • BCYM3
  • CMT2C
  • SPSMA
  • TRP12
  • VROAC
  • HMSN2C
  • OTRPC4
  • SSQTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.91
cellular component
0.91
protein domain
0.85
kinase
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 842.2   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 842.2   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 274
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Gene Ontology Terms (77)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (127)
1 – 10 of 127
TRPC1
Tbio
Family: IC
Novelty: 0.00278663
Score: 0.92
Data Source: STRINGDB
TRPM8
Tclin
Family: IC
Novelty: 0.00200706
Score: 0.905
Data Source: STRINGDB
PKD2
Tchem
Family: IC
Novelty: 0.00208049
Score: 0.873
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00331843
Score: 0.867
Data Source: STRINGDB
PACSIN3
Tbio
Family: Enzyme
Novelty: 0.17960231
Score: 0.851
Data Source: STRINGDB
TRPC3
Tchem
Family: IC
Novelty: 0.00309492
Score: 0.825
Data Source: STRINGDB
TRPC6
Tchem
Family: IC
Novelty: 0.00139594
Score: 0.822
Data Source: STRINGDB
PRKCE
Tchem
Family: Kinase
Novelty: 0.01268488
Score: 0.821
Data Source: STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00099987
Score: 0.802
Data Source: STRINGDB
PRKCD
Tclin
Family: Kinase
Novelty: 0.00129351
Score: 0.801
Data Source: STRINGDB
Publication Statistics
PubMed Score  842.20

PubMed score by year
PubTator Score  417.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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