Tchem TRPV4 Transient receptor potential cation channel subfamily V member 4

Protein Summary

Description

Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). Isoform 5: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. Isoform 2: Lacks channel activity, due to impaired oligomerization and intracellular retention. Isoform 4: Lacks channel activity, due to impaired oligomerization and intracellular retention. Isoform 6: Lacks channel activity, due to impaired oligomerization and intracellular retention. This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q9HBA0
• B7ZKQ6
• Q17R79
• Q2Y122
• Q2Y123
• Q2Y124
• Q86YZ6
• Q8NDY7
• Q8NG64
• Q96Q92
• Q96RS7
• Q9HBC0
• TrpV4

Gene Name

• TRPV4

Ensembl ID

• ENST00000261740
• ENSP00000261740
• ENSG00000111199
• ENST00000418703
• ENSP00000406191
• ENST00000536838
• ENSP00000444336
• ENST00000537083
• ENSP00000442738
• ENST00000541794
• ENSP00000442167
• ENST00000544971
• ENSP00000443611

Symbol

• VRL2
• VROAC
• SMAL
• VRL2
• BCYM3
• CMT2C
• SPSMA
• TRP12
• VROAC
• HMSN2C
• OTRPC4
• SSQTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.91
cellular component	0.91
protein domain	0.85
kinase	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily V Member 4

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Trpv Subfamily / Trpv4 Sub-subfamily / Transient Receptor Potential Cation Channel Subfamily V Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1259.12   (req: < 5)

Gene RIFs: 270   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1259.12   (req: >= 5)

Gene RIFs: 270   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 475

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0