Tchem NMUR1 Neuromedin-U receptor 1

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Neuromedin-u Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuromedin U Receptor / Neuromedin-u Receptor 1

Protein Summary

Description

Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Uniprot Accession IDs

• Q9HB89
• O43664
• Q7LDP6
• Q8NE20
• NMU-R1

Gene Name

• NMUR1

Ensembl ID

• ENST00000305141
• ENSP00000305877
• ENSG00000171596

Symbol

• GPR66
• FM3
• FM-3
• GPC-R
• GPR66
• NMU1R
• (FM-3)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.64
microRNA	0.61
protein domain	0.58
cell type or tissue	0.57
gene perturbation	0.55

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.76   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.76   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

CHEMBL3759452

NMUR1Tchem GPCR

EC50: 9.24

CHEMBL3758577

NMUR1Tchem GPCR

EC50: 9.25

CHEMBL3758687

NMUR1Tchem GPCR

EC50: 7.23

CHEMBL3760037

NMUR1Tchem GPCR

EC50: 8.75

CHEMBL3759206

NMUR1Tchem GPCR

EC50: 7.91

CHEMBL3759820

NMUR1Tchem GPCR

EC50: 7.32

Pathways (10)

Reactome (8)

KEGG (1)

WikiPathways (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (16)

Functions (4)

Components (3)

Processes (9)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
neuromedin U binding	Inferred from Direct Assay (IDA)	UniProtKB
neuromedin U receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
G protein-coupled receptor activity	Traceable Author Statement (TAS)	UniProtKB
neuropeptide receptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (357)

Explore Interacting Targets

1 – 10 of 357

• See Interactions on String-DB

NMU

Tbio

Novelty: 0.00347523

Score: 0.993

Data Source: Reactome,STRINGDB

NMS

Tbio

Novelty: 0.03848674

Score: 0.985

Data Source: STRINGDB

GNRHR

Tclin

Family: GPCR

Novelty: 0.00227536

Score: 0.942

Data Source: STRINGDB

NTS

Tbio

Novelty: 0.00035891

Score: 0.94

Data Source: STRINGDB

NPS

Tbio

Novelty: 0.00011983

Score: 0.928

Data Source: STRINGDB

GNAQ

Tbio

Novelty: 0.00176666

Score: 0.927

Data Source: STRINGDB

POMC

Tbio

Novelty: 0.00002654

Score: 0.927

Data Source: STRINGDB

TBXA2R

Tclin

Family: GPCR

Novelty: 0.00629658

Score: 0.926

Data Source: STRINGDB

GAL

Tbio

Novelty: 0.00057698

Score: 0.925

Data Source: STRINGDB

S1PR4

Tclin

Family: GPCR

Novelty: 0.01383323

Score: 0.924

Data Source: STRINGDB

Publication Statistics

PubMed Score  116.76

PubMed score by year

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PubTator Score  55.6

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLI

1-70

FVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLL

70-140

FEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCR

140-210

GPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSR

210-280

YTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSA

280-350

ANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQ

350-420

QETDPS

420-426

MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS

Find similar targets by:

Uniprot Keyword

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane