Tchem NMUR1 Neuromedin-U receptor 1

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Neuromedin-u Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuromedin U Receptor / Neuromedin-u Receptor 1

Protein Summary

Description

Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Uniprot Accession IDs

• Q9HB89
• O43664
• Q7LDP6
• Q8NE20
• NMU-R1

Gene Name

• NMUR1

Ensembl ID

• ENST00000305141
• ENSP00000305877
• ENSG00000171596

Symbol

• GPR66
• FM3
• FM-3
• GPC-R
• GPR66
• NMU1R
• (FM-3)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.64
microRNA	0.61
protein domain	0.58
cell type or tissue	0.57
gene perturbation	0.55

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.7   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.7   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

CHEMBL3758687

NMUR1Tchem GPCR

EC50 : 7.23

CHEMBL3759820

NMUR1Tchem GPCR

EC50 : 7.32

CHEMBL3759206

NMUR1Tchem GPCR

EC50 : 7.91

CHEMBL3760037

NMUR1Tchem GPCR

EC50 : 8.75

CHEMBL3759452

NMUR1Tchem GPCR

EC50 : 9.24

CHEMBL3758577

NMUR1Tchem GPCR

EC50 : 9.25

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neuromedin U receptor 1	VGNC:2714	739217
Mouse	neuromedin U receptor 1	MGI:1341898	14767
Rat	neuromedin U receptor 1	RGD:619867	65276
Dog	neuromedin U receptor 1 [Source:HGNC Symbol;Acc:HGNC:4518]
Horse	neuromedin U receptor 1	VGNC:20786	100064205

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neuromedin U receptor 1
Mouse	neuromedin U receptor 1
Rat	neuromedin U receptor 1
Dog	neuromedin U receptor 1 [Source:HGNC Symbol;Acc:HGNC:4518]
Horse	neuromedin U receptor 1

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9HB89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)

Reactome (8)

KEGG (1)

WikiPathways (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (16)

Functions (4)

Components (3)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
neuromedin U binding	Inferred from Direct Assay (IDA)	UniProtKB
neuromedin U receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
G protein-coupled receptor activity	Traceable Author Statement (TAS)	UniProtKB
neuropeptide receptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (357)

Explore Interacting Targets

1 – 10 of 357

• See Interactions on String-DB

NMU

Tbio

Novelty: 0.00326109

Score: 0.993

Data Source: Reactome,STRINGDB

NMS

Tbio

Novelty: 0.03324369

Score: 0.985

Data Source: STRINGDB

GNRHR

Tclin

Family: GPCR

Novelty: 0.00203671

Score: 0.942

Data Source: STRINGDB

NTS

Tbio

Novelty: 0.00033201

Score: 0.94

Data Source: STRINGDB

NPS

Tbio

Novelty: 0.00692108

Score: 0.928

Data Source: STRINGDB

GNAQ

Tbio

Novelty: 0.0008997

Score: 0.927

Data Source: STRINGDB

POMC

Tbio

Novelty: 0.00002436

Score: 0.927

Data Source: STRINGDB

TBXA2R

Tclin

Family: GPCR

Novelty: 0.00571066

Score: 0.926

Data Source: STRINGDB

GAL

Tbio

Novelty: 0.0005132

Score: 0.925

Data Source: STRINGDB

S1PR4

Tclin

Family: GPCR

Novelty: 0.01523676

Score: 0.924

Data Source: STRINGDB

Publication Statistics

PubMed Score  137.70

PubMed score by year

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PubTator Score  55.6

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane

MGI Phenotype Find Similar Targets

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homeostasis/metabolism phenotype