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Tbio
PIDD1
p53-induced death domain-containing protein 1

Protein Summary
Description
Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900). The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347755
  • ENSP00000337797
  • ENSG00000177595
  • ENST00000411829
  • ENSP00000416801

Symbol
  • LRDD
  • PIDD
  • LRDD
  • PIDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.83
disease
0.73
tissue
0.72
gene perturbation
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.18   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.18   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
91.5
mean platelet volume
2
2
2
89.4
intraocular pressure measurement
2
3
3
89
waist-hip ratio
4
6
9
86.9
Keratoconus
2
2
1
6.6
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
91.5
mean platelet volume
2
89.4
intraocular pressure measurement
3
89
waist-hip ratio
9
86.9
Keratoconus
1
6.6
82.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
p53-induced death domain protein 1
700580
Mouse
MGI:1889507
57913
Pig
p53-induced death domain protein 1
102167527
Zebrafish
ZDB-GENE-081104-353
571033
Species
Name
OMA
EggNOG
Inparanoid
Macaque
p53-induced death domain protein 1
Mouse
Pig
p53-induced death domain protein 1
Zebrafish
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HB75-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome
TP53 Regulates Transcription of Cell Death Genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Cell Death Genes
Protein-Protein Interactions (79)
1 – 10 of 79
CRADD
Tbio
Novelty:  0.02761299
Score:  0.998
Data Source:  Reactome,STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.992
Data Source:  Reactome,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.974
Data Source:  Reactome,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.959
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.958
Data Source:  STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.954
Data Source:  STRINGDB
MADD
Tbio
Family:  Enzyme
Novelty:  0.01590443
Score:  0.94
Data Source:  STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.939
Data Source:  STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.928
Data Source:  STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
Score:  0.927
Data Source:  STRINGDB
Publication Statistics
PubMed Score  69.18

PubMed score by year
PubTator Score  40.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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