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Tbio
CACYBP
Calcyclin-binding protein

Protein Summary
Description
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367679
  • ENSP00000356652
  • ENSG00000116161
  • ENST00000405362
  • ENSP00000385771
  • ENST00000406752
  • ENSP00000384139
  • ENST00000613570
  • ENSP00000479414

Symbol
  • S100A6BP
  • SIP
  • SIP
  • GIG5
  • PNAS-107
  • S100A6BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.98
kinase perturbation
0.97
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.15   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.15   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling miserable measurement
1
1
0
5.8
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling miserable measurement
0
5.8
19.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcyclin binding protein
VGNC:459
457537
Macaque
calcyclin binding protein
709343
Mouse
MGI:1270839
12301
Rat
RGD:1303146
289144
Dog
calcyclin binding protein
480062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcyclin binding protein
Macaque
calcyclin binding protein
Mouse
Rat
Dog
calcyclin binding protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HB71-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (99)
1 – 10 of 99
SNX4
Tbio
Novelty: 0.05441145
p_int: 0.933642029
p_ni: 0.066357971
Score: 0.696
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.90878801
p_ni: 0.09121199
Data Source: BioPlex
SIAH1
Tbio
Family: Enzyme
Novelty: 0.00831224
Score: 0.989
Data Source: STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
Score: 0.976
Data Source: STRINGDB
S100A6
Tbio
Novelty: 0.00176164
Score: 0.975
Data Source: STRINGDB
SUGT1
Tbio
Novelty: 0.1042721
Score: 0.961
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.948
Data Source: STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
Score: 0.916
Data Source: STRINGDB
AXIN1
Tbio
Novelty: 0.00175842
Score: 0.905
Data Source: STRINGDB
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.15

PubMed score by year
PubTator Score  37.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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