Tbio NTN4 Netrin-4

Protein Classes

PANTHER Classes

Protein / Receptor / Netrin-4

Protein / Extracellular Matrix Protein / Extracellular Matrix Linker Protein / Netrin-4

Protein / ... / Protease Inhibitor / Netrin-4

Protein Summary

Description

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9HB63
• B2RNC2
• Q658K9
• Q7L3F1
• Q7L9D6
• Q7Z5B6
• Q9BZP1
• Q9NT44
• Q9P133

Gene Name

• NTN4

Ensembl ID

• ENST00000343702
• ENSP00000340998
• ENSG00000074527
• ENST00000344911
• ENSP00000339436
• ENST00000538383
• ENSP00000444432
• ENST00000553059
• ENSP00000447292

Symbol

• PRO3091

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
transcription factor perturbation	0.74
protein domain	0.73
PubMedID	0.72
histone modification site profile	0.65

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.72   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.72   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (9)

Reactome (5)

KEGG (1)

PathwayCommons (3)

Axon guidance (R-HSA-422475)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Netrin-1 signaling	49 targets	R-HSA-373752
Reactome	Non-integrin membrane-ECM interactions	43 targets	R-HSA-3000171

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
Extracellular matrix organization	297 targets	R-HSA-1474244
Netrin-1 signaling	49 targets	R-HSA-373752
Non-integrin membrane-ECM interactions	43 targets	R-HSA-3000171

Gene Ontology Terms (6)

Functions (1)

Components (2)

Processes (3)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
laminin-1 binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

DCC

Tbio

Novelty: 0.00810253

Score: 0.973

Data Source: Reactome,STRINGDB

UNC5A

Tbio

Novelty: 0.05365755

Score: 0.972

Data Source: Reactome,STRINGDB

LAMC1

Tbio

Novelty: 0.01596649

Score: 0.944

Data Source: STRINGDB

LAMC3

Tbio

Novelty: 0.03317215

Score: 0.938

Data Source: STRINGDB

LAMA1

Tbio

Novelty: 0.01015308

Score: 0.938

Data Source: STRINGDB

LAMA3

Tbio

Novelty: 0.0024184

Score: 0.934

Data Source: STRINGDB

LAMA2

Tbio

Novelty: 0.00237711

Score: 0.931

Data Source: STRINGDB

LAMA5

Tbio

Novelty: 0.02842048

Score: 0.931

Data Source: STRINGDB

LAMA4

Tbio

Novelty: 0.02106699

Score: 0.931

Data Source: STRINGDB

LAMB1

Tbio

Novelty: 0.01303566

Score: 0.913

Data Source: STRINGDB

Publication Statistics

PubMed Score  36.72

PubMed score by year

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PubTator Score  27.38

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDL

1-70

TCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPA

70-140

AMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENP

140-210

YSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPV

210-280

KAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEA

280-350

SGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDC

350-420

PCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWE

420-490

WEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIF

490-560

RGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK

560-628

MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK

Find similar targets by:

Uniprot Keyword

Alternative splicing
Basement membrane
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Laminin EGF-like domain
Polymorphism
Reference proteome
Repeat