Protein Summary
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
- ENST00000343702
- ENSP00000340998
- ENSG00000074527
- ENST00000344911
- ENSP00000339436
- ENST00000538383
- ENSP00000444432
- ENST00000553059
- ENSP00000447292
- PRO3091
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.75 | ||
transcription factor perturbation | 0.74 | ||
protein domain | 0.73 | ||
PubMedID | 0.72 | ||
histone modification site profile | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.55 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 175 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.55 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 175 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0