Protein Classes
Protein Summary
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
- ENST00000343702
- ENSP00000340998
- ENSG00000074527
- ENST00000344911
- ENSP00000339436
- ENST00000538383
- ENSP00000444432
- ENST00000553059
- ENSP00000447292
- PRO3091
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.75 | ||
transcription factor perturbation | 0.74 | ||
protein domain | 0.73 | ||
PubMedID | 0.72 | ||
histone modification site profile | 0.65 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.82 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 175 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.82 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 175 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 1 | 1 | 32.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 32.1 | |||||
Orthologs (12)
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (9)
Reactome (5)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Netrin-1 signaling | ||||
Reactome | Non-integrin membrane-ECM interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Extracellular matrix organization | ||||
Netrin-1 signaling | ||||
Non-integrin membrane-ECM interactions | ||||
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (32)
1 – 10 of 32
DCC
Novelty: 0.01273911
Score: 0.973
Data Source: Reactome,STRINGDB
UNC5A
Novelty: 0.03749855
Score: 0.972
Data Source: Reactome,STRINGDB
LAMC1
Novelty: 0.01230796
Score: 0.944
Data Source: STRINGDB
LAMC3
Novelty: 0.02221768
Score: 0.938
Data Source: STRINGDB
LAMA1
Novelty: 0.00852401
Score: 0.938
Data Source: STRINGDB
LAMA3
Novelty: 0.00733792
Score: 0.934
Data Source: STRINGDB
LAMA2
Novelty: 0.00210486
Score: 0.931
Data Source: STRINGDB
LAMA5
Novelty: 0.02247145
Score: 0.931
Data Source: STRINGDB
LAMA4
Novelty: 0.01288371
Score: 0.931
Data Source: STRINGDB
LAMB1
Novelty: 0.0104285
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score 43.82
PubMed score by year
PubTator Score 27.38
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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