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Tbio
NTN4
Netrin-4

Protein Summary
Description
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343702
  • ENSP00000340998
  • ENSG00000074527
  • ENST00000344911
  • ENSP00000339436
  • ENST00000538383
  • ENSP00000444432
  • ENST00000553059
  • ENSP00000447292

Symbol
  • PRO3091
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
transcription factor perturbation
0.74
protein domain
0.73
PubMedID
0.72
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.82   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.82   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
32.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
32.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
netrin 4
VGNC:5510
467098
Macaque
netrin 4
712628
Mouse
MGI:1888978
57764
Rat
RGD:1565947
299737
Dog
netrin 4
VGNC:44009
475431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
netrin 4
Macaque
netrin 4
Mouse
Rat
Dog
netrin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HB63-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Extracellular matrix organization
Reactome
Netrin-1 signaling
Reactome
Non-integrin membrane-ECM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Extracellular matrix organization
Netrin-1 signaling
Non-integrin membrane-ECM interactions
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (32)
1 – 10 of 32
DCC
Tbio
Novelty: 0.01273911
Score: 0.973
Data Source: Reactome,STRINGDB
UNC5A
Tbio
Novelty: 0.03749855
Score: 0.972
Data Source: Reactome,STRINGDB
LAMC1
Tbio
Novelty: 0.01230796
Score: 0.944
Data Source: STRINGDB
LAMC3
Tbio
Novelty: 0.02221768
Score: 0.938
Data Source: STRINGDB
LAMA1
Tbio
Novelty: 0.00852401
Score: 0.938
Data Source: STRINGDB
LAMA3
Tbio
Novelty: 0.00733792
Score: 0.934
Data Source: STRINGDB
LAMA2
Tbio
Novelty: 0.00210486
Score: 0.931
Data Source: STRINGDB
LAMA5
Tbio
Novelty: 0.02247145
Score: 0.931
Data Source: STRINGDB
LAMA4
Tbio
Novelty: 0.01288371
Score: 0.931
Data Source: STRINGDB
LAMB1
Tbio
Novelty: 0.0104285
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.82

PubMed score by year
PubTator Score  27.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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