Protein Classes
Protein Summary
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
- ENST00000343702
- ENSP00000340998
- ENSG00000074527
- ENST00000344911
- ENSP00000339436
- ENST00000538383
- ENSP00000444432
- ENST00000553059
- ENSP00000447292
- PRO3091
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 0.75 | ||
transcription factor perturbation | 0.74 | ||
protein domain | 0.73 | ||
PubMedID | 0.72 | ||
histone modification site profile | 0.65 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.72 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 175 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.72 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 175 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (9)
Reactome (5)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Netrin-1 signaling | ||||
Reactome | Non-integrin membrane-ECM interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Extracellular matrix organization | ||||
Netrin-1 signaling | ||||
Non-integrin membrane-ECM interactions | ||||
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (32)
1 – 10 of 32
DCC
Novelty: 0.00810253
Score: 0.973
Data Source: Reactome,STRINGDB
UNC5A
Novelty: 0.05365755
Score: 0.972
Data Source: Reactome,STRINGDB
LAMC1
Novelty: 0.01596649
Score: 0.944
Data Source: STRINGDB
LAMC3
Novelty: 0.03317215
Score: 0.938
Data Source: STRINGDB
LAMA1
Novelty: 0.01015308
Score: 0.938
Data Source: STRINGDB
LAMA3
Novelty: 0.0024184
Score: 0.934
Data Source: STRINGDB
LAMA2
Novelty: 0.00237711
Score: 0.931
Data Source: STRINGDB
LAMA5
Novelty: 0.02842048
Score: 0.931
Data Source: STRINGDB
LAMA4
Novelty: 0.02106699
Score: 0.931
Data Source: STRINGDB
LAMB1
Novelty: 0.01303566
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score 36.72
PubMed score by year
PubTator Score 27.38
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDL
1-70
TCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPA
70-140
AMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENP
140-210
YSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPV
210-280
KAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEA
280-350
SGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDC
350-420
PCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWE
420-490
WEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIF
490-560
RGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK
560-628
MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK
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