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Tbio
SP110
Sp110 nuclear body protein

Protein Summary
Description
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258381
  • ENSP00000258381
  • ENSG00000135899
  • ENST00000258382
  • ENSP00000258382
  • ENST00000358662
  • ENSP00000351488
  • ENST00000540870
  • ENSP00000439558

Symbol
  • IPR1
  • VODI
  • IFI41
  • IFI75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
transcription factor perturbation
0.96
disease perturbation
0.83
tissue sample
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.12   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.12   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (51)
1 – 10 of 51
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.875
Data Source:  STRINGDB
SAMD9L
Tbio
Novelty:  0.03957268
Score:  0.776
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.776
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.761
Data Source:  STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.756
Data Source:  STRINGDB
XAF1
Tbio
Novelty:  0.01458015
Score:  0.739
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.732
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.699
Data Source:  STRINGDB
OAS1
Tbio
Family:  Enzyme
Novelty:  0.00532331
Score:  0.692
Data Source:  STRINGDB
IFI35
Tbio
Novelty:  0.04309126
Score:  0.687
Data Source:  STRINGDB
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
93.3
4
2
0
1.4
90.5
serum non-albumin protein measurement
1
3
3
87.6
eosinophil count
3
2
3
85.6
eosinophil percentage of leukocytes
2
2
2
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
93.3
0
1.4
90.5
serum non-albumin protein measurement
3
87.6
eosinophil count
3
85.6
eosinophil percentage of leukocytes
2
83.4
Find similar targets by:
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1310173
301570
Dog
SP110 nuclear body protein
VGNC:46685
100686387
Pig
SP110 nuclear body protein
100519278
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
SP110 nuclear body protein
Pig
SP110 nuclear body protein
Publication Statistics
PubMed Score 44.12
PubMed score by year
PubTator Score 87.92
PubTator score by year