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Tbio
IL1RL2
Interleukin-1 receptor-like 2

Protein Summary
Description
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 recept ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264257
  • ENSP00000264257
  • ENSG00000115598
  • ENST00000441515
  • ENSP00000413348

Symbol
  • IL1RRP2
  • IL-36R
  • IL1RRP2
  • IL-1Rrp2
  • IL1R-rp2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.7
gene perturbation
0.65
PubMedID
0.58
tissue sample
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.73   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.73   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
10
1
1.2
99.1
serum ST2 measurement
1
8
8
99.1
7
6
4
1.1
98.1
4
3
0
1.2
97.1
childhood onset asthma
2
3
0
1.4
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
99.1
serum ST2 measurement
8
99.1
4
1.1
98.1
0
1.2
97.1
childhood onset asthma
0
1.4
95.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor like 2
VGNC:6391
470456
Macaque
interleukin 1 receptor like 2
711812
Mouse
MGI:1913107
107527
Rat
RGD:621782
171106
Dog
interleukin 1 receptor like 2
611453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor like 2
Macaque
interleukin 1 receptor like 2
Mouse
Rat
Dog
interleukin 1 receptor like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HB29-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-36 pathway
Reactome
Interleukin-38 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-36 pathway
Interleukin-38 signaling
Protein-Protein Interactions (32)
1 – 10 of 32
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999996667
p_ni:  0.000003332
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
DNAJC6
Tbio
Family:  Enzyme
Novelty:  0.01359669
p_int:  0.999988337
p_ni:  0.000008012
p_wrong:  0.000003651
Score:  0.379
Data Source:  BioPlex,STRINGDB
MYO1F
Tbio
Novelty:  0.06367196
p_int:  0.948723889
p_ni:  0.050340954
p_wrong:  0.000935157
Score:  0.199
Data Source:  BioPlex,STRINGDB
MICAL1
Tbio
Family:  Enzyme
Novelty:  0.02668048
p_int:  0.892001185
p_ni:  0.107998656
p_wrong:  1.59e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.862529639
p_ni:  0.137470361
Score:  0.154
Data Source:  BioPlex,STRINGDB
GET4
Tbio
Novelty:  0.03516005
p_int:  0.831718554
p_ni:  0.168281446
Score:  0.199
Data Source:  BioPlex,STRINGDB
IL36RN
Tbio
Novelty:  0.00659649
Score:  0.991
Data Source:  Reactome,STRINGDB
IL1F10
Tbio
Novelty:  0.01868526
Score:  0.983
Data Source:  Reactome,STRINGDB
IL36B
Tbio
Novelty:  0.05952789
Score:  0.972
Data Source:  Reactome,STRINGDB
IL36A
Tbio
Novelty:  0.03569425
Score:  0.971
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  78.73

PubMed score by year
PubTator Score  23.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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