Tbio PLEKHA3 Pleckstrin homology domain-containing family A member 3

Protein Summary

Description

Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).

Uniprot Accession IDs

• Q9HB20
• Q4ZG69
• Q86TQ1
• Q9NXT3
• PH domain-containing family A member 3

Gene Name

• PLEKHA3

Ensembl ID

• ENST00000234453
• ENSP00000234453
• ENSG00000116095

Symbol

• FAPP1
• FAPP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
histone modification site profile	0.75
tissue sample	0.73
transcription factor binding site profile	0.68
gene perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Pleckstrin Homology Domain-containing Family A Member 3

DTO Classes

Protein / Transporter / Pleckstrin Homology Domain-containing Family A Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0