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Tbio
KCNK13
Potassium channel subfamily K member 13

Protein Summary
Description
Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282146
  • ENSP00000282146
  • ENSG00000152315

Symbol
  • THIK1
  • THIK-1
  • K2p13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
histone modification site profile
0.8
molecular function
0.79
tissue sample
0.69
transcription factor binding site profile
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 13
VGNC:7445
737631
Macaque
potassium two pore domain channel subfamily K member 13 [Source:HGNC Symbol;Acc:HGNC:6275]
Mouse
MGI:2384976
217826
Rat
RGD:68941
64120
Dog
potassium two pore domain channel subfamily K member 13
VGNC:53499
490829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 13
Macaque
potassium two pore domain channel subfamily K member 13 [Source:HGNC Symbol;Acc:HGNC:6275]
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HB14-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (15)
1 – 10 of 15
KCNK18
Tclin
Family: IC
Novelty: 0.01151961
Score: 0.808
Data Source: STRINGDB
CHL1
Tbio
Novelty: 0.00055237
Score: 0.544
Data Source: STRINGDB
TTC7B
Tbio
Novelty: 0.22257455
Score: 0.526
Data Source: STRINGDB
CASC4
Tbio
Novelty: 0.05791147
Score: 0.494
Data Source: STRINGDB
SUPT3H
Tbio
Novelty: 0.13202683
Score: 0.494
Data Source: STRINGDB
SEC31B
Tdark
Novelty: 0.35742768
Score: 0.474
Data Source: STRINGDB
PSME4
Tbio
Novelty: 0.01206213
Score: 0.45
Data Source: STRINGDB
FAM78A
Tdark
Novelty: 0.92171591
Score: 0.445
Data Source: STRINGDB
ERLEC1
Tbio
Novelty: 0.01243855
Score: 0.44
Data Source: STRINGDB
FBXO34
Tdark
Novelty: 5.6683456
Score: 0.422
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.25

PubMed score by year
PubTator Score  7.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer