Tbio BCL2L12 Bcl-2-like protein 12

Protein Summary

Description

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q9HB09
• Q3SY11
• Q3SY13
• Q96I96
• Q9HB08
• Bcl2-L-12

Gene Name

• BCL2L12

Ensembl ID

• ENST00000246785
• ENSP00000246785
• ENSG00000126453
• ENST00000441864
• ENSP00000393803
• ENST00000616144
• ENSP00000482218

Symbol

• BPR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
biological process	0.74
tissue sample	0.71
ligand (protein) perturbation	0.59
transcription factor binding site profile	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.41   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.41   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0