You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRDM16
PR domain zinc finger protein 16

Protein Summary
Description
Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated ve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270722
  • ENSP00000270722
  • ENSG00000142611
  • ENST00000378391
  • ENSP00000367643

Symbol
  • KIAA1675
  • MEL1
  • PFM13
  • MEL1
  • KMT8F
  • LVNC8
  • PFM13
  • CMD1LL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
protein domain
0.85
biological process
0.82
microRNA
0.72
phenotype
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.56   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.56   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
99
mean platelet volume
3
2
4
88.1
hematocrit
3
2
3
83.3
mean corpuscular hemoglobin concentration
1
1
1
79.8
platelet crit
2
3
4
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
99
mean platelet volume
4
88.1
hematocrit
3
83.3
mean corpuscular hemoglobin concentration
1
79.8
platelet crit
4
74.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 16
VGNC:1468
457227
Mouse
MGI:1917923
70673
Rat
RGD:2324431
100366024
Dog
PR/SET domain 16
VGNC:44948
479582
Horse
PR/SET domain 16
VGNC:21815
100060844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 16
Mouse
Rat
Dog
PR/SET domain 16
Horse
PR/SET domain 16
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (94)
1 – 10 of 94
SPDEF
Tbio
Family: TF
Novelty: 0.00618802
p_int: 0.999999988
p_wrong: 1.2e-8
Score: 0.544
Data Source: BioPlex,STRINGDB
UCP1
Tbio
Novelty: 0.00055954
Score: 0.92
Data Source: STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00142673
Score: 0.915
Data Source: STRINGDB
CIDEA
Tbio
Novelty: 0.00901749
Score: 0.859
Data Source: STRINGDB
ZNF516
Tbio
Family: TF
Novelty: 0.22650006
Score: 0.853
Data Source: STRINGDB
EBF2
Tbio
Family: TF
Novelty: 0.00921566
Score: 0.795
Data Source: STRINGDB
TMEM26
Tdark
Novelty: 0.07174624
Score: 0.772
Data Source: STRINGDB
TLE3
Tbio
Novelty: 0.02641884
Score: 0.743
Data Source: STRINGDB
DIO2
Tbio
Family: Enzyme
Novelty: 0.00173094
Score: 0.742
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score  369.56

PubMed score by year
PubTator Score  128.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: