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Tchem
CLK4
Dual specificity protein kinase CLK4

Protein Summary
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this k ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316308
  • ENSP00000316948
  • ENSG00000113240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.98
molecular function
0.94
disease perturbation
0.87
transcription factor binding site profile
0.83
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999998037
p_ni: 8.34e-7
p_wrong: 0.000001129
Score: 0.19
Data Source: BioPlex,STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.999996488
p_ni: 0.000003208
p_wrong: 3.04e-7
Data Source: BioPlex
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999992115
p_ni: 0.000007806
p_wrong: 7.9e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
CLK1
Tchem
Family: Kinase
Novelty: 0.00812732
Score: 0.956
Data Source: STRINGDB
PRPF39
Tdark
Novelty: 0.35760414
Score: 0.741
Data Source: STRINGDB
SRPK1
Tchem
Family: Kinase
Novelty: 0.01066655
Score: 0.713
Data Source: STRINGDB
PNISR
Tdark
Novelty: 0.06559175
Score: 0.676
Data Source: STRINGDB
PAXBP1
Tbio
Novelty: 0.13631396
Score: 0.664
Data Source: STRINGDB
SRSF5
Tbio
Novelty: 0.01658346
Score: 0.657
Data Source: STRINGDB
RBM23
Tbio
Novelty: 0.03769792
Score: 0.651
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.73

PubMed score by year
PubTator Score  11.28

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer