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Tchem
CLK4
Dual specificity protein kinase CLK4

Protein Summary
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this k ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316308
  • ENSP00000316948
  • ENSG00000113240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.98
molecular function
0.94
disease perturbation
0.87
transcription factor binding site profile
0.83
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 167
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (54)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999998037
p_ni:  8.34e-7
p_wrong:  0.000001129
Score:  0.19
Data Source:  BioPlex,STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.999996488
p_ni:  0.000003208
p_wrong:  3.04e-7
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.999992115
p_ni:  0.000007806
p_wrong:  7.9e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
CLK1
Tchem
Family:  Kinase
Novelty:  0.00812732
Score:  0.956
Data Source:  STRINGDB
PRPF39
Tbio
Novelty:  0.35760414
Score:  0.741
Data Source:  STRINGDB
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
Score:  0.713
Data Source:  STRINGDB
PNISR
Tdark
Novelty:  0.06559175
Score:  0.676
Data Source:  STRINGDB
PAXBP1
Tbio
Novelty:  0.13631396
Score:  0.664
Data Source:  STRINGDB
SRSF5
Tbio
Novelty:  0.01658346
Score:  0.657
Data Source:  STRINGDB
RBM23
Tbio
Novelty:  0.03769792
Score:  0.651
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
42.3
neutrophil percentage of leukocytes
1
1
1
38.2
granulocyte percentage of myeloid white cells
1
1
1
28.1
1
1
0
1.1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
42.3
neutrophil percentage of leukocytes
1
38.2
granulocyte percentage of myeloid white cells
1
28.1
0
1.1
27.3
Find similar targets by:
IDG Resources
Chemical Tool
4-(6-ethoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(3-methoxyphenyl)pyrimidin-2-amine
image for 4-(6-ethoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(3-methoxyphenyl)pyrimidin-2-amine
Details:
  • ChEBI:  143118
  • Provider:  UNC-CH
  • Activity:  867 nM
  • Selectivity:  0.042
Chemical Tool
N-(3-methoxy-5-(trifluoromethyl)phenyl)-4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
image for N-(3-methoxy-5-(trifluoromethyl)phenyl)-4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
Details:
  • ChEBI:  156443
  • Provider:  UNC-CH
  • Activity:  867 nM
  • Selectivity:  0.042
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC like kinase 4
VGNC:3953
471811
Macaque
CDC like kinase 4
702752
Mouse
MGI:1098551
12750
Dog
CDC like kinase 4
VGNC:39349
474645
Horse
CDC like kinase 4
VGNC:16622
100058051
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC like kinase 4
Macaque
CDC like kinase 4
Mouse
Dog
CDC like kinase 4
Horse
CDC like kinase 4
Publication Statistics
PubMed Score 20.89
PubMed score by year
PubTator Score 11.28
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title