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Tbio
BCO1
Beta,beta-carotene 15,15'-dioxygenase

Protein Summary
Description
Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258168
  • ENSP00000258168
  • ENSG00000135697

Symbol
  • BCDO
  • BCDO1
  • BCMO1
  • BCO
  • BCDO
  • BCMO
  • BCDO1
  • BCMO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
histone modification site profile
0.66
disease
0.61
biological term
0.49
biological process
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.72   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.72   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0