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Tbio
BCO1
Beta,beta-carotene 15,15'-dioxygenase

Protein Summary
Description
Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258168
  • ENSP00000258168
  • ENSG00000135697

Symbol
  • BCDO
  • BCDO1
  • BCMO1
  • BCO
  • BCDO
  • BCMO
  • BCDO1
  • BCMO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
histone modification site profile
0.66
disease
0.61
biological term
0.49
biological process
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.43   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.43   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carotenoid measurement
1
1
1
31.2
tocopherol measurement
1
1
1
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carotenoid measurement
1
31.2
tocopherol measurement
1
31.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-carotene oxygenase 1
VGNC:5680
468043
Mouse
MGI:1926923
63857
Rat
RGD:70981
114106
Dog
beta-carotene oxygenase 1
VGNC:38417
489695
Horse
beta-carotene oxygenase 1
VGNC:15800
100069873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-carotene oxygenase 1
Mouse
Rat
Dog
beta-carotene oxygenase 1
Horse
beta-carotene oxygenase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAY6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
ABLIM1
Tbio
Novelty:  0.05511373
p_int:  0.999332416
p_ni:  0.000667549
p_wrong:  3.5e-8
Score:  0.54
Data Source:  BioPlex,STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.948
Data Source:  STRINGDB
ISX
Tbio
Family:  TF
Novelty:  0.01913008
Score:  0.936
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.934
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.932
Data Source:  STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
Score:  0.931
Data Source:  STRINGDB
RDH11
Tbio
Family:  Enzyme
Novelty:  0.02758936
Score:  0.928
Data Source:  STRINGDB
RDH8
Tbio
Family:  Enzyme
Novelty:  0.06071472
Score:  0.927
Data Source:  STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
Score:  0.927
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.923
Data Source:  STRINGDB
Publication Statistics
PubMed Score  140.43

PubMed score by year
PubTator Score  44.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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