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Tbio
UGT1A10
UDP-glucuronosyltransferase 1-10

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344644
  • ENSP00000343838
  • ENSG00000242515
  • ENST00000373445
  • ENSP00000362544

Symbol
  • GNT1
  • UGT1
  • GNT1
  • UGT1
  • UDPGT
  • UGT1A
  • UGT1J
  • UGT-1A
  • UGT-1J
  • UGT1.1
  • UGT1A1
  • UGT1-01
  • UGT1-10
  • UGT1.10
  • hUG-BR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
chemical
0.95
molecular function
0.88
disease
0.82
phenotype
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.83   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.83   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
UGT1A9
Tbio
Family:  Enzyme
Novelty:  0.0047848
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
UGT1A7
Tbio
Family:  Enzyme
Novelty:  0.01095445
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
S100A7A
Tbio
Novelty:  0.06518939
p_int:  0.998892784
p_ni:  0.000133863
p_wrong:  0.000973354
Score:  0.234
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.996451839
p_ni:  0.003548161
Data Source:  BioPlex
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.994589897
p_ni:  0.005409696
p_wrong:  4.07e-7
Score:  0.22
Data Source:  BioPlex,STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.992686973
p_ni:  0.002599376
p_wrong:  0.004713651
Score:  0.218
Data Source:  BioPlex,STRINGDB
CRABP2
Tchem
Novelty:  0.0050363
p_int:  0.980927246
p_ni:  0.000998724
p_wrong:  0.01807403
Score:  0.247
Data Source:  BioPlex,STRINGDB
CALML5
Tbio
Novelty:  0.03240679
p_int:  0.966331585
p_ni:  0.033668415
Data Source:  BioPlex
IGKC
Tdark
p_int:  0.959362888
p_ni:  0.040637104
p_wrong:  8e-9
Data Source:  BioPlex
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.931255132
p_ni:  0.008690612
p_wrong:  0.060054256
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (19)
Biological oxidations (R-HSA-211859)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
17
78
144
100
vitamin D measurement
4
5
5
96.7
blood metabolite measurement
1
2
8
95.6
testosterone measurement
7
4
7
92.6
serum metabolite measurement
2
2
10
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
144
100
vitamin D measurement
5
96.7
blood metabolite measurement
8
95.6
testosterone measurement
7
92.6
serum metabolite measurement
10
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 61.83
PubMed score by year
PubTator Score 60.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title