Tbio CLSPN Claspin

Protein Summary

Description

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q9HAW4
• A6NFL4
• Q1RMC6
• Q2KHM3
• Q5VYG0
• Q6P6H5
• Q8IWI1
• hClaspin

Gene Name

• CLSPN

Ensembl ID

• ENST00000251195
• ENSP00000251195
• ENSG00000092853
• ENST00000318121
• ENSP00000312995
• ENST00000373220
• ENSP00000362317

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.87
biological process	0.79
gene perturbation	0.79
small molecule perturbation	0.79
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.02   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.02   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0