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Tbio
CLSPN
Claspin

Protein Summary
Description
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251195
  • ENSP00000251195
  • ENSG00000092853
  • ENST00000318121
  • ENSP00000312995
  • ENST00000373220
  • ENSP00000362317
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.87
biological process
0.79
gene perturbation
0.79
small molecule perturbation
0.79
transcription factor perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.09   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.09   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claspin
VGNC:1220
456746
Mouse
MGI:2445153
269582
Rat
RGD:1309083
298534
Dog
claspin
VGNC:39362
482481
Horse
claspin
VGNC:16636
100055244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claspin
Mouse
Rat
Dog
claspin
Horse
claspin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Cell Cycle
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.99999828
p_ni: 0.000001716
p_wrong: 5e-9
Data Source: BioPlex
GINS3
Tbio
Novelty: 0.02892519
p_int: 0.999998208
p_ni: 0.00000154
p_wrong: 2.52e-7
Score: 0.748
Data Source: BioPlex,STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.999
Data Source: STRINGDB
RPA3
Tbio
Novelty: 0.00887858
Score: 0.999
Data Source: STRINGDB
RPA2
Tbio
Novelty: 0.00879115
Score: 0.999
Data Source: STRINGDB
CHEK1
Tchem
Family: Kinase
Novelty: 0.00066843
Score: 0.997
Data Source: Reactome,STRINGDB
RAD17
Tbio
Novelty: 0.00640979
Score: 0.997
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.994
Data Source: STRINGDB
PRIMPOL
Tbio
Family: Enzyme
Novelty: 0.01285041
Score: 0.994
Data Source: STRINGDB
CDC45
Tbio
Novelty: 0.00515457
Score: 0.99
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  76.09

PubMed score by year
PubTator Score  46.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer