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Tbio
CLSPN
Claspin

Protein Summary
Description
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251195
  • ENSP00000251195
  • ENSG00000092853
  • ENST00000318121
  • ENSP00000312995
  • ENST00000373220
  • ENSP00000362317
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.87
biological process
0.79
gene perturbation
0.79
small molecule perturbation
0.79
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.98   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.98   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (207)
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.99999828
p_ni:  0.000001716
p_wrong:  5e-9
Data Source:  BioPlex
GINS3
Tbio
Novelty:  0.02892519
p_int:  0.999998208
p_ni:  0.00000154
p_wrong:  2.52e-7
Score:  0.748
Data Source:  BioPlex,STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.999
Data Source:  STRINGDB
RPA3
Tbio
Novelty:  0.00887858
Score:  0.999
Data Source:  STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.999
Data Source:  STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
Score:  0.997
Data Source:  Reactome,STRINGDB
RAD17
Tbio
Novelty:  0.00640979
Score:  0.997
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.994
Data Source:  STRINGDB
PRIMPOL
Tbio
Family:  Enzyme
Novelty:  0.01285041
Score:  0.994
Data Source:  STRINGDB
CDC45
Tbio
Novelty:  0.00515457
Score:  0.99
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Cell Cycle
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
59
1
1
0
1.1
15.8
mean corpuscular volume
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
59
0
1.1
15.8
mean corpuscular volume
1
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claspin
VGNC:1220
456746
Mouse
MGI:2445153
269582
Rat
RGD:1309083
298534
Dog
claspin
VGNC:39362
482481
Horse
claspin
VGNC:16636
100055244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claspin
Mouse
Rat
Dog
claspin
Horse
claspin
Publication Statistics
PubMed Score 78.98
PubMed score by year
PubTator Score 46.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title