Tbio BRF2 Transcription factor IIIB 50 kDa subunit

Protein Summary

Description

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HAW0
• B2RD62
• B4DFZ6
• D3DSW6
• Q9H2Y3
• Q9H3B3
• Q9NUY6
• TFIIIB50

Gene Name

• BRF2

Ensembl ID

• ENST00000220659
• ENSP00000220659
• ENSG00000104221

Symbol

• BRFU
• BRFU
• TFIIIB50

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
transcription factor binding site profile	0.74
cell line	0.59
tissue sample	0.57
cell type or tissue	0.54

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Iiib 50 Kda Subunit

DTO Classes

Protein / Transcription Factor / Transcription Factor Iiib 50 Kda Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.13   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.13   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0