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Tbio
XPO5
Exportin-5

Protein Classes
Protein Summary
Description
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
histone modification site profile
0.9
virus perturbation
0.9
transcription factor perturbation
0.88
transcription factor binding site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.1   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.1   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
24.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
24.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exportin 5
VGNC:3790
472014
Macaque
exportin 5
700664
Mouse
MGI:1913789
72322
Rat
RGD:1311522
363194
Dog
exportin 5
VGNC:48462
474913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exportin 5
Macaque
exportin 5
Mouse
Rat
Dog
exportin 5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
MicroRNA (miRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
MicroRNA (miRNA) biogenesis
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
CLEC12A
Tbio
Novelty: 0.01478908
p_int: 0.999771535
p_ni: 0.000228465
Score: 0.205
Data Source: BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.994262458
p_ni: 0.005737542
Score: 0.169
Data Source: BioPlex,STRINGDB
TMEM130
Tdark
Novelty: 1.39618601
p_int: 0.987813731
p_ni: 0.012186269
Data Source: BioPlex
VSIG2
Tdark
Novelty: 0.32398032
p_int: 0.963747912
p_ni: 0.036252088
Score: 0.169
Data Source: BioPlex,STRINGDB
RALB
Tbio
Family: Enzyme
Novelty: 0.01605746
p_int: 0.903314533
p_ni: 0.096685467
Score: 0.245
Data Source: BioPlex,STRINGDB
VSTM1
Tbio
Novelty: 0.08630646
p_int: 0.890378007
p_ni: 0.109621993
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.881164454
p_ni: 0.118835546
Data Source: BioPlex
PVR
Tbio
Novelty: 0.00215811
p_int: 0.877388904
p_ni: 0.122611096
Score: 0.179
Data Source: BioPlex,STRINGDB
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.83855265
p_ni: 0.16144735
Data Source: BioPlex
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.83686178
p_ni: 0.16313822
Data Source: BioPlex
Publication Statistics
PubMed Score  200.10

PubMed score by year
PubTator Score  71.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer