Tbio GNB4 Guanine nucleotide-binding protein subunit beta-4

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HAV0
• B3KMH5
• D3DNR8

Gene Name

• GNB4

Ensembl ID

• ENST00000232564
• ENSP00000232564
• ENSG00000114450
• ENST00000468623
• ENSP00000419693

Symbol

• CMTD1F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
protein domain	0.92
transcription factor perturbation	0.91
microRNA	0.86
pathway	0.86

Protein Classes

PANTHER Classes

Protein / Hydrolase / Guanine Nucleotide-binding Protein Subunit Beta-4

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein Subunit Beta-4

DTO Classes

Protein / Enzyme / Hydrolase / Guanine Nucleotide-binding Protein Subunit Beta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (587)

Explore Interacting Targets

1 – 10 of 587

• See Interactions on String-DB

GNG2

Tbio

Novelty:  0.04807242

p_int:  0.999999216

p_ni:  7.84e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

GNGT1

Tbio

Novelty:  0.05291961

p_int:  0.999996337

p_ni:  0.000003663

Score:  0.999

Data Source:  BioPlex,STRINGDB

GNG3

Tbio

Novelty:  0.16941216

p_int:  0.999960626

p_ni:  0.000039372

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

P63092

Tbio

Novelty:  0.00284739

p_int:  0.999727486

p_ni:  0.000272514

Score:  0.964

Data Source:  BioPlex,Reactome,STRINGDB

GNAI1

Tbio

Novelty:  0.0488971

p_int:  0.999654373

p_ni:  0.000345627

Score:  0.991

Data Source:  BioPlex,STRINGDB

GNG4

Tbio

Novelty:  0.14371438

p_int:  0.998619542

p_ni:  0.00122695

p_wrong:  0.000153508

Score:  0.999

Data Source:  BioPlex,STRINGDB

GNAI3

Tbio

Novelty:  0.03484857

p_int:  0.998493831

p_ni:  0.001506168

p_wrong:  1e-9

Score:  0.989

Data Source:  BioPlex,STRINGDB

GNAI2

Tchem

Novelty:  0.03014729

p_int:  0.994298471

p_ni:  0.005701222

p_wrong:  3.07e-7

Score:  0.989

Data Source:  BioPlex,STRINGDB

GNA13

Tbio

Novelty:  0.04149138

p_int:  0.98437158

p_ni:  0.01562842

Score:  0.957

Data Source:  BioPlex,STRINGDB

GALK2

Tbio

Family:  Kinase

Novelty:  0.06382824

p_int:  0.943481139

p_ni:  0.056518561

p_wrong:  2.99e-7

Score:  0.231

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (26)

Explore Nearest Tclin Targets

Upstream (16)

Downstream (10)

1 – 5 of 16

F2R

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  2

1: PI3K-Akt signaling pathway

2: Pathways in cancer

CHRM1

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  2

1: PI3K-Akt signaling pathway

2: Cholinergic synapse

CHRM2

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  2

1: PI3K-Akt signaling pathway

2: Cholinergic synapse

CNR1

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  1

1: Retrograde endocannabinoid signaling

GABBR1

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  2

1: GABAergic synapse

2: Morphine addiction

Pathways (102)

Reactome (51)

KEGG (18)

PathwayCommons (27)

WikiPathways (6)

ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Find Similar Targets

Items per page:

5

1 – 5 of 51

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ADP signalling through P2Y purinoceptor 1	25 targets	R-HSA-418592
Reactome	ADP signalling through P2Y purinoceptor 12	22 targets	R-HSA-392170
Reactome	Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Reactome	Adrenaline,noradrenaline inhibits insulin secretion	28 targets	R-HSA-400042
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717

Name	Explore in Pharos	Explore in Source
ADP signalling through P2Y purinoceptor 1	25 targets	R-HSA-418592
ADP signalling through P2Y purinoceptor 12	22 targets	R-HSA-392170
Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Adrenaline,noradrenaline inhibits insulin secretion	28 targets	R-HSA-400042
Aquaporin-mediated transport	55 targets	R-HSA-445717

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (4)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	MGI

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	1	1	1		54.4
atrial fibrillation	EFO_0000275	2	3	0	1.1	46.8
platelet crit	EFO_0007985	1	1	1		29
heart rate	EFO_0004326	1	1	1		17.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	1		54.4
atrial fibrillation	EFO_0000275	0	1.1	46.8
platelet crit	EFO_0007985	1		29
heart rate	EFO_0004326	1		17.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Charcot-Marie-Tooth disease
Complete proteome
Direct protein sequencing
Disease mutation
Neurodegeneration
Neuropathy
Phosphoprotein
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
diastolic blood pressure
heart rate
platelet crit

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	G protein subunit beta 4	VGNC:8836	460862
Macaque	G protein subunit beta 4		709489
Mouse	guanine nucleotide binding protein (G protein), beta 4	MGI:104581	14696
Rat	G protein subunit beta 4	RGD:1359321	294962
Dog	G protein subunit beta 4	VGNC:41315	488087

Species	Name	OMA	EggNOG	Inparanoid
Chimp	G protein subunit beta 4
Macaque	G protein subunit beta 4
Mouse	guanine nucleotide binding protein (G protein), beta 4
Rat	G protein subunit beta 4
Dog	G protein subunit beta 4

Publication Statistics

PubMed Score 15.36

PubMed score by year

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PubTator Score 7.04

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (9)

Items per page:

10

0 of 0

PMID	Year	Title