GNB4
Guanine nucleotide-binding protein subunit beta-4
Protein Classes
Protein Summary
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
- ENST00000232564
- ENSP00000232564
- ENSG00000114450
- ENST00000468623
- ENSP00000419693
- CMTD1F
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
protein domain | 0.92 | ||
transcription factor perturbation | 0.91 | ||
microRNA | 0.86 | ||
pathway | 0.86 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.2 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.2 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 1 | 1 | 43.2 | |||||
1 | 1 | 0 | 1.1 | 34.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 43.2 | |||||
0 | 1.1 | 34.6 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | G protein subunit beta 4 | VGNC:8836 | 460862 | |||||
Macaque | G protein subunit beta 4 | 709489 | ||||||
Mouse | MGI:104581 | 14696 | ||||||
Rat | RGD:1359321 | 294962 | ||||||
Dog | G protein subunit beta 4 | VGNC:41315 | 488087 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | G protein subunit beta 4 | |||||
Macaque | G protein subunit beta 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein subunit beta 4 | |||||
Pathways (102)
Reactome (51)
KEGG (18)
PathwayCommons (27)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 51
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ADP signalling through P2Y purinoceptor 1 | ||||
Reactome | ADP signalling through P2Y purinoceptor 12 | ||||
Reactome | Activation of kainate receptors upon glutamate binding | ||||
Reactome | Adrenaline,noradrenaline inhibits insulin secretion | ||||
Reactome | Aquaporin-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ADP signalling through P2Y purinoceptor 1 | ||||
ADP signalling through P2Y purinoceptor 12 | ||||
Activation of kainate receptors upon glutamate binding | ||||
Adrenaline,noradrenaline inhibits insulin secretion | ||||
Aquaporin-mediated transport | ||||
Gene Ontology Terms (8)
Functions (1)
Components (4)
Processes (3)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Protein-Protein Interactions (587)
1 – 10 of 587
GNG2
Novelty: 0.04807242
p_int: 0.999999216
p_ni: 7.84e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNGT1
Novelty: 0.05291961
p_int: 0.999996337
p_ni: 0.000003663
Score: 0.999
Data Source: BioPlex,STRINGDB
GNG3
Novelty: 0.16941216
p_int: 0.999960626
p_ni: 0.000039372
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAS
Novelty: 0.00284739
p_int: 0.999727486
p_ni: 0.000272514
Score: 0.964
Data Source: BioPlex,Reactome,STRINGDB
GNAI1
Novelty: 0.0488971
p_int: 0.999654373
p_ni: 0.000345627
Score: 0.991
Data Source: BioPlex,STRINGDB
GNG4
Novelty: 0.14371438
p_int: 0.998619542
p_ni: 0.00122695
p_wrong: 0.000153508
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAI3
Novelty: 0.03484857
p_int: 0.998493831
p_ni: 0.001506168
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
GNAI2
Novelty: 0.03014729
p_int: 0.994298471
p_ni: 0.005701222
p_wrong: 3.07e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
GNA13
Novelty: 0.04149138
p_int: 0.98437158
p_ni: 0.01562842
Score: 0.957
Data Source: BioPlex,STRINGDB
GALK2
Family: Kinase
Novelty: 0.06382824
p_int: 0.943481139
p_ni: 0.056518561
p_wrong: 2.99e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 12.20
PubMed score by year
PubTator Score 7.04
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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