Tbio GNB4 Guanine nucleotide-binding protein subunit beta-4

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HAV0
• B3KMH5
• D3DNR8

Gene Name

• GNB4

Ensembl ID

• ENST00000232564
• ENSP00000232564
• ENSG00000114450
• ENST00000468623
• ENSP00000419693

Symbol

• CMTD1F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
protein domain	0.92
transcription factor perturbation	0.91
microRNA	0.86
pathway	0.86

Protein Classes

PANTHER Classes

Protein / Hydrolase / Guanine Nucleotide-binding Protein Subunit Beta-4

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein Subunit Beta-4

DTO Classes

Protein / Enzyme / Hydrolase / Guanine Nucleotide-binding Protein Subunit Beta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.15   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.15   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0