Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

GNB4

Ensembl ID

ENST00000232564
ENSP00000232564
ENSG00000114450
ENST00000468623
ENSP00000419693

Symbol

CMTD1F

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99

protein domain	0.92

transcription factor perturbation	0.91

microRNA	0.86

pathway	0.86

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.2 (req: < 5)

View Publications

Gene RIFs: 9 (req: <= 3)

View Gene RIFs

Antibodies: 156 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.2 (req: >= 5)

Gene RIFs: 9 (req: > 3)

Antibodies: 156 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
diastolic blood pressure	EFO_0006336	1	1	1		43.2

atrial fibrillation	EFO_0000275	1	1	0	1.1	34.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
diastolic blood pressure	EFO_0006336	1		43.2

atrial fibrillation	EFO_0000275	0	1.1	34.6

Beta Count

Odds Ratio

Pathways (102)

Reactome (51)

KEGG (18)

PathwayCommons (27)

WikiPathways (6)

ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 51

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ADP signalling through P2Y purinoceptor 1	25 targets	R-HSA-418592

Reactome	ADP signalling through P2Y purinoceptor 12	22 targets	R-HSA-392170

Reactome	Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326

Reactome	Adrenaline,noradrenaline inhibits insulin secretion	28 targets	R-HSA-400042

Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717

Name	Explore in Pharos	Explore in Source
ADP signalling through P2Y purinoceptor 1	25 targets	R-HSA-418592

ADP signalling through P2Y purinoceptor 12	22 targets	R-HSA-392170

Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326

Adrenaline,noradrenaline inhibits insulin secretion	28 targets	R-HSA-400042

Aquaporin-mediated transport	55 targets	R-HSA-445717

Gene Ontology Terms (8)

Functions (1)

Components (4)

Processes (3)

Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	MGI

Protein-Protein Interactions (587)

1 – 10 of 587

See Interactions on String-DB

GNG2

Tbio

Novelty: 0.04807242

p_int: 0.999999216

p_ni: 7.84e-7

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

GNGT1

Tbio

Novelty: 0.05291961

p_int: 0.999996337

p_ni: 0.000003663

Score: 0.999

Data Source: BioPlex,STRINGDB

GNG3

Tbio

Novelty: 0.16941216

p_int: 0.999960626

p_ni: 0.000039372

p_wrong: 1e-9

Score: 0.999

Data Source: BioPlex,STRINGDB

GNAS

Tbio

Novelty: 0.00284739

p_int: 0.999727486

p_ni: 0.000272514

Score: 0.964

Data Source: BioPlex,Reactome,STRINGDB

GNAI1

Tbio

Novelty: 0.0488971

p_int: 0.999654373

p_ni: 0.000345627

Score: 0.991

Data Source: BioPlex,STRINGDB

GNG4

Tbio

Novelty: 0.14371438

p_int: 0.998619542

p_ni: 0.00122695

p_wrong: 0.000153508

Score: 0.999

Data Source: BioPlex,STRINGDB

GNAI3

Tbio

Novelty: 0.03484857

p_int: 0.998493831

p_ni: 0.001506168

p_wrong: 1e-9

Score: 0.989

Data Source: BioPlex,STRINGDB

GNAI2

Tbio

Novelty: 0.03014729

p_int: 0.994298471

p_ni: 0.005701222

p_wrong: 3.07e-7

Score: 0.989

Data Source: BioPlex,STRINGDB

GNA13

Tbio

Novelty: 0.04149138

p_int: 0.98437158

p_ni: 0.01562842

Score: 0.957

Data Source: BioPlex,STRINGDB

GALK2

Tbio

Family: Kinase

Novelty: 0.06382824

p_int: 0.943481139

p_ni: 0.056518561

p_wrong: 2.99e-7

Score: 0.231

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score 12.20

PubMed score by year

PubTator Score 7.04

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword


Acetylation

Charcot-Marie-Tooth disease

Complete proteome

Direct protein sequencing

Disease mutation

Neurodegeneration

Neuropathy

Phosphoprotein

Reference proteome

Repeat

GWAS Trait

MGI Phenotype


cardiovascular system phenotype

hematopoietic system phenotype

immune system phenotype