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Tbio
UPF2
Regulator of nonsense transcripts 2

Protein Summary
Description
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356352
  • ENSP00000348708
  • ENSG00000151461
  • ENST00000357604
  • ENSP00000350221
  • ENST00000397053
  • ENSP00000380244

Symbol
  • KIAA1408
  • RENT2
  • HUPF2
  • RENT2
  • smg-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
interacting protein
0.94
disease perturbation
0.87
histone modification site profile
0.67
transcription factor
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.95   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.95   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UPF2, regulator of nonsense mediated mRNA decay
VGNC:14871
450304
Mouse
MGI:2449307
326622
Rat
RGD:1309178
361271
Dog
UPF2, regulator of nonsense mediated mRNA decay
VGNC:48151
487130
Horse
UPF2, regulator of nonsense mediated mRNA decay
VGNC:24805
100069342
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UPF2, regulator of nonsense mediated mRNA decay
Mouse
Rat
Dog
UPF2, regulator of nonsense mediated mRNA decay
Horse
UPF2, regulator of nonsense mediated mRNA decay
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (237)
1 – 10 of 237
RNPS1
Tbio
Novelty: 0.03203224
Score: 0.999
Data Source: Reactome,STRINGDB
UPF3B
Tbio
Novelty: 0.03482348
Score: 0.999
Data Source: Reactome,STRINGDB
RBM8A
Tbio
Novelty: 0.00052175
Score: 0.999
Data Source: Reactome,STRINGDB
UPF3A
Tbio
Novelty: 0.01431609
Score: 0.999
Data Source: Reactome,STRINGDB
SMG1
Tchem
Family: Kinase
Novelty: 0.00854339
Score: 0.999
Data Source: STRINGDB
UPF1
Tbio
Novelty: 0.00311006
Score: 0.999
Data Source: STRINGDB
SRRM1
Tbio
Novelty: 0.03770186
Score: 0.996
Data Source: STRINGDB
SMG6
Tbio
Family: Enzyme
Novelty: 0.0217417
Score: 0.995
Data Source: STRINGDB
SMG5
Tbio
Novelty: 0.04143189
Score: 0.994
Data Source: STRINGDB
SMG7
Tbio
Novelty: 0.03394393
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.95

PubMed score by year
PubTator Score  38.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer