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Tbio
SMURF2
E3 ubiquitin-protein ligase SMURF2

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262435
  • ENSP00000262435
  • ENSG00000108854
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
biological process
0.89
interacting protein
0.84
kinase perturbation
0.81
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.66   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.66   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
4.8
vital capacity
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
4.8
vital capacity
1
2.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMAD specific E3 ubiquitin protein ligase 2
VGNC:9638
454761
Macaque
SMAD specific E3 ubiquitin protein ligase 2
717902
Mouse
MGI:1913563
66313
Rat
RGD:1310067
303614
Horse
SMAD specific E3 ubiquitin protein ligase 2
VGNC:23365
100064082
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMAD specific E3 ubiquitin protein ligase 2
Macaque
SMAD specific E3 ubiquitin protein ligase 2
Mouse
Rat
Horse
SMAD specific E3 ubiquitin protein ligase 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HAU4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (126)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (428)
1 – 10 of 428
SMURF1
Tchem
Family: Enzyme
Novelty: 0.00754708
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00405952
p_int: 0.999999913
p_ni: 5.8e-8
p_wrong: 3e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
p_int: 0.999999089
p_ni: 9.1e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
SEMG2
Tbio
Novelty: 0.06325799
p_int: 0.999998452
p_ni: 0.000001548
Score: 0.183
Data Source: BioPlex,STRINGDB
MARS2
Tbio
Family: Enzyme
Novelty: 0.02533315
p_int: 0.999989794
p_ni: 0.000010205
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
ARHGAP5
Tbio
Family: Enzyme
Novelty: 0.03683127
p_int: 0.999972752
p_ni: 0.000027248
Score: 0.361
Data Source: BioPlex,STRINGDB
LINGO2
Tbio
Novelty: 0.06112205
p_int: 0.999815954
p_ni: 0.000184046
Score: 0.19
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.998611343
p_ni: 0.001312434
p_wrong: 0.000076223
Score: 0.614
Data Source: BioPlex,STRINGDB
NEDD4
Tchem
Family: Enzyme
Novelty: 0.00281725
p_int: 0.99038598
p_ni: 0.00961402
p_wrong: 1e-9
Score: 0.957
Data Source: BioPlex,STRINGDB
CUEDC1
Tbio
Novelty: 0.14401061
p_int: 0.974652491
p_ni: 0.006209181
p_wrong: 0.019138328
Data Source: BioPlex
Publication Statistics
PubMed Score  117.66

PubMed score by year
PubTator Score  65.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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