SMURF2
E3 ubiquitin-protein ligase SMURF2
Protein Classes
Protein Summary
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
- ENST00000262435
- ENSP00000262435
- ENSG00000108854
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.92 | ||
biological process | 0.89 | ||
interacting protein | 0.84 | ||
kinase perturbation | 0.81 | ||
virus perturbation | 0.68 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 117.66 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 117.66 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 4.8 | |||||
vital capacity | 1 | 1 | 1 | 2.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 4.8 | |||||
vital capacity | 1 | 2.8 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SMAD specific E3 ubiquitin protein ligase 2 | VGNC:9638 | 454761 | |||||
Macaque | SMAD specific E3 ubiquitin protein ligase 2 | 717902 | ||||||
Mouse | MGI:1913563 | 66313 | ||||||
Rat | RGD:1310067 | 303614 | ||||||
Horse | SMAD specific E3 ubiquitin protein ligase 2 | VGNC:23365 | 100064082 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Macaque | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Mouse | ||||||
Rat | ||||||
Horse | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (126)
Reactome (29)
KEGG (4)
PathwayCommons (8)
UniProt (1)
WikiPathways (84)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 29
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Class I MHC mediated antigen processing & presentation | ||||
Gene Ontology Terms (29)
Functions (5)
Components (8)
Processes (16)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (428)
1 – 10 of 428
SMURF1
Family: Enzyme
Novelty: 0.00754708
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
SMAD5
Family: TF
Novelty: 0.00405952
p_int: 0.999999913
p_ni: 5.8e-8
p_wrong: 3e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
SMAD1
Family: TF
Novelty: 0.02348173
p_int: 0.999999089
p_ni: 9.1e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
SEMG2
Novelty: 0.06325799
p_int: 0.999998452
p_ni: 0.000001548
Score: 0.183
Data Source: BioPlex,STRINGDB
MARS2
Family: Enzyme
Novelty: 0.02533315
p_int: 0.999989794
p_ni: 0.000010205
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
ARHGAP5
Family: Enzyme
Novelty: 0.03683127
p_int: 0.999972752
p_ni: 0.000027248
Score: 0.361
Data Source: BioPlex,STRINGDB
LINGO2
Novelty: 0.06112205
p_int: 0.999815954
p_ni: 0.000184046
Score: 0.19
Data Source: BioPlex,STRINGDB
LDLRAD4
Novelty: 0.04881486
p_int: 0.998611343
p_ni: 0.001312434
p_wrong: 0.000076223
Score: 0.614
Data Source: BioPlex,STRINGDB
NEDD4
Family: Enzyme
Novelty: 0.00281725
p_int: 0.99038598
p_ni: 0.00961402
p_wrong: 1e-9
Score: 0.957
Data Source: BioPlex,STRINGDB
CUEDC1
Novelty: 0.14401061
p_int: 0.974652491
p_ni: 0.006209181
p_wrong: 0.019138328
Data Source: BioPlex
Publication Statistics
PubMed Score 117.66
PubMed score by year
PubTator Score 65.12
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword