SMURF2
E3 ubiquitin-protein ligase SMURF2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 0.92 | ||
biological process | 0.89 | ||
interacting protein | 0.84 | ||
kinase perturbation | 0.81 | ||
virus perturbation | 0.68 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Class I MHC mediated antigen processing & presentation | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 1 | 2 | 68.6 | |||||
sex hormone-binding globulin measurement | 2 | 2 | 2 | 49.2 | |||||
cardiac troponin I measurement | 1 | 1 | 1 | 48.5 | |||||
vital capacity | 1 | 2 | 2 | 42 | |||||
1 | 1 | 0 | 1 | 24.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 68.6 | |||||
sex hormone-binding globulin measurement | 2 | 49.2 | |||||
cardiac troponin I measurement | 1 | 48.5 | |||||
vital capacity | 2 | 42 | |||||
0 | 1 | 24.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SMAD specific E3 ubiquitin protein ligase 2 | VGNC:9638 | 454761 | |||||
Macaque | SMAD specific E3 ubiquitin protein ligase 2 | 717902 | ||||||
Mouse | MGI:1913563 | 66313 | ||||||
Rat | RGD:1310067 | 303614 | ||||||
Horse | SMAD specific E3 ubiquitin protein ligase 2 | VGNC:23365 | 100064082 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Macaque | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Mouse | ||||||
Rat | ||||||
Horse | SMAD specific E3 ubiquitin protein ligase 2 | |||||
PMID | Year | Title |
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