SMURF2
E3 ubiquitin-protein ligase SMURF2
Protein Summary
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
- ENST00000262435
- ENSP00000262435
- ENSG00000108854
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.92 | ||
biological process | 0.89 | ||
interacting protein | 0.84 | ||
kinase perturbation | 0.81 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 121.16 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 121.16 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (428)
SMAD5
Family: TF
Novelty: 0.00405952
p_int: 0.999999913
p_ni: 5.8e-8
p_wrong: 3e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
SMAD1
Family: TF
Novelty: 0.02348173
p_int: 0.999999089
p_ni: 9.1e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
SEMG2
Novelty: 0.06325799
p_int: 0.999998452
p_ni: 0.000001548
Score: 0.183
Data Source: BioPlex,STRINGDB
MARS2
Family: Enzyme
Novelty: 0.02533315
p_int: 0.999989794
p_ni: 0.000010205
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
ARHGAP5
Family: Enzyme
Novelty: 0.03683127
p_int: 0.999972752
p_ni: 0.000027248
Score: 0.361
Data Source: BioPlex,STRINGDB
LINGO2
Novelty: 0.06112205
p_int: 0.999815954
p_ni: 0.000184046
Score: 0.19
Data Source: BioPlex,STRINGDB
LDLRAD4
Novelty: 0.04881486
p_int: 0.998611343
p_ni: 0.001312434
p_wrong: 0.000076223
Score: 0.614
Data Source: BioPlex,STRINGDB
NEDD4
Family: Enzyme
Novelty: 0.00281725
p_int: 0.99038598
p_ni: 0.00961402
p_wrong: 1e-9
Score: 0.957
Data Source: BioPlex,STRINGDB
CUEDC1
Novelty: 0.14401061
p_int: 0.974652491
p_ni: 0.006209181
p_wrong: 0.019138328
Data Source: BioPlex
Nearest Tclin Targets (7)
Upstream (1)
Downstream (6)
1 – 1 of 1
Pathways (126)
Reactome (29)
KEGG (4)
PathwayCommons (8)
UniProt (1)
WikiPathways (84)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Class I MHC mediated antigen processing & presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (5)
Components (8)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 1 | 2 | 68.6 | |||||
sex hormone-binding globulin measurement | 2 | 2 | 2 | 49.2 | |||||
cardiac troponin I measurement | 1 | 1 | 1 | 48.5 | |||||
vital capacity | 1 | 2 | 2 | 42 | |||||
1 | 1 | 0 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 68.6 | |||||
sex hormone-binding globulin measurement | 2 | 49.2 | |||||
cardiac troponin I measurement | 1 | 48.5 | |||||
vital capacity | 2 | 42 | |||||
0 | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SMAD specific E3 ubiquitin protein ligase 2 | VGNC:9638 | 454761 | |||||
Macaque | SMAD specific E3 ubiquitin protein ligase 2 | 717902 | ||||||
Mouse | MGI:1913563 | 66313 | ||||||
Rat | RGD:1310067 | 303614 | ||||||
Horse | SMAD specific E3 ubiquitin protein ligase 2 | VGNC:23365 | 100064082 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Macaque | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Mouse | ||||||
Rat | ||||||
Horse | SMAD specific E3 ubiquitin protein ligase 2 | |||||
Publication Statistics
PubMed Score 121.16
PubMed score by year
PubTator Score 65.12
PubTator score by year
Related Publications
Text Mined References (81)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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