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Tbio
PELI2
E3 ubiquitin-protein ligase pellino homolog 2

Protein Summary
Description
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267460
  • ENSP00000267460
  • ENSG00000139946
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
PubMedID
0.72
microRNA
0.71
biological process
0.66
histone modification site profile
0.66


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pellino E3 ubiquitin protein ligase family member 2
699169
Mouse
MGI:1891445
93834
Rat
RGD:1565884
305835
Dog
pellino E3 ubiquitin protein ligase family member 2
VGNC:44415
106559103
Cow
pellino E3 ubiquitin protein ligase family member 2
VGNC:32741
100337503
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pellino E3 ubiquitin protein ligase family member 2
Mouse
Rat
Dog
pellino E3 ubiquitin protein ligase family member 2
Cow
pellino E3 ubiquitin protein ligase family member 2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IRAK1 recruits IKK complex
Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Immune System
Innate Immune System
Protein-Protein Interactions (26)
1 – 10 of 26
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.988
Data Source: Reactome,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.967
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.955
Data Source: Reactome,STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.919
Data Source: STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
Score: 0.918
Data Source: STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.911
Data Source: Reactome,STRINGDB
UBE2V1
Tbio
Novelty: 0.01642178
Score: 0.908
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.908
Data Source: STRINGDB
PELI1
Tbio
Family: Enzyme
Novelty: 0.0479662
Score: 0.905
Data Source: Reactome,STRINGDB
PELI3
Tbio
Family: Enzyme
Novelty: 0.16212379
Score: 0.901
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  5.66

PubMed score by year
PubTator Score  3.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer