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Tbio
LMAN1L
Protein ERGIC-53-like

Protein Summary
Description
This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309664
  • ENSP00000310431
  • ENSG00000140506
  • ENST00000379709
  • ENSP00000369031

Symbol
  • ERGL
  • ERGL
  • ERGIC-53L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.58
PubMedID
0.48
cell line
0.44
tissue
0.4
biological term
0.36


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (51)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
3
5
89.6
coffee consumption measurement
4
2
4
89
coffee consumption
5
3
6
88.6
glomerular filtration rate
4
2
6
82.7
creatinine measurement
2
2
3
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
89.6
coffee consumption measurement
4
89
coffee consumption
6
88.6
glomerular filtration rate
6
82.7
creatinine measurement
3
82.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lectin, mannose binding 1 like
467826
Mouse
MGI:2667537
235416
Rat
RGD:1310538
300743
Dog
lectin, mannose binding 1 like
VGNC:42707
487650
Horse
lectin, mannose binding 1 like
VGNC:19698
100062212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lectin, mannose binding 1 like
Mouse
Rat
Dog
lectin, mannose binding 1 like
Horse
lectin, mannose binding 1 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Membrane Trafficking
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (79)
1 – 10 of 79
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.94
Data Source:  STRINGDB
STX5
Tbio
Novelty:  0.00964918
Score:  0.933
Data Source:  STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.927
Data Source:  STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.927
Data Source:  STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.922
Data Source:  STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.919
Data Source:  STRINGDB
SEC31A
Tbio
Novelty:  0.0350228
Score:  0.918
Data Source:  STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
Score:  0.917
Data Source:  STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.916
Data Source:  STRINGDB
LMAN2
Tbio
Novelty:  0.02922729
Score:  0.916
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.65

PubMed score by year
PubTator Score  2.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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