Tbio ROPN1 Ropporin-1A

Protein Summary

Description

Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9HAT0
• D3DN99
• Q9UF38

Gene Name

• ROPN1

Ensembl ID

• ENST00000184183
• ENSP00000184183
• ENSG00000065371
• ENST00000405845
• ENSP00000385919
• ENST00000459660
• ENSP00000420590
• ENST00000479867
• ENSP00000420567
• ENST00000484329
• ENSP00000419205
• ENST00000495093
• ENSP00000417379
• ENST00000620893
• ENSP00000483603

Symbol

• ROPN1A
• CT91
• ODF6
• ROPN1A
• RHPNAP1
• ropporin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.64
cell type or tissue	0.56
gene perturbation	0.56
cell line	0.45
tissue	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0