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Tbio
ROPN1
Ropporin-1A

Protein Summary
Description
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000184183
  • ENSP00000184183
  • ENSG00000065371
  • ENST00000405845
  • ENSP00000385919
  • ENST00000459660
  • ENSP00000420590
  • ENST00000479867
  • ENSP00000420567
  • ENST00000484329
  • ENSP00000419205
  • ENST00000495093
  • ENSP00000417379
  • ENST00000620893
  • ENSP00000483603

Symbol
  • ROPN1A
  • CT91
  • ODF6
  • ROPN1A
  • RHPNAP1
  • ropporin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.64
cell type or tissue
0.56
gene perturbation
0.56
cell line
0.45
tissue
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.91   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.91   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
ROPN1B
Tbio
Novelty:  3.84148772
p_int:  1
Score:  0.719
Data Source:  BioPlex,STRINGDB
MBNL1
Tbio
Novelty:  0.00441241
p_int:  0.997590304
p_ni:  0.002382684
p_wrong:  0.000027012
Score:  0.309
Data Source:  BioPlex,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.872991686
p_ni:  0.127008256
p_wrong:  5.7e-8
Score:  0.516
Data Source:  BioPlex,STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.752003938
p_ni:  0.247996062
Score:  0.189
Data Source:  BioPlex,STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
Score:  0.988
Data Source:  Reactome,STRINGDB
AKAP3
Tbio
Family:  Enzyme
Novelty:  0.030936
Score:  0.943
Data Source:  STRINGDB
SPA17
Tbio
Novelty:  0.02632554
Score:  0.937
Data Source:  STRINGDB
RHPN2
Tbio
Novelty:  0.04808006
Score:  0.925
Data Source:  STRINGDB
CABYR
Tbio
Novelty:  0.0414671
Score:  0.907
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.902
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Rhotekin and Rhophilins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Rhotekin and Rhophilins
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
1
21.5
household income
2
1
2
10.5
mathematical ability
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
21.5
household income
2
10.5
mathematical ability
1
6.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhophilin associated tail protein 1
VGNC:2540
460642
Mouse
MGI:1923628
76378
Rat
RGD:1310675
288053
Dog
rhophilin associated tail protein 1
488013
Horse
rhophilin associated tail protein 1
100070460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhophilin associated tail protein 1
Mouse
Rat
Dog
rhophilin associated tail protein 1
Horse
rhophilin associated tail protein 1
Publication Statistics
PubMed Score 19.91
PubMed score by year
PubTator Score 10.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title