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Tchem
SLC28A3
Solute carrier family 28 member 3

Protein Summary
Description
Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376238
  • ENSP00000365413
  • ENSG00000197506

Symbol
  • CNT3
  • CNT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.85
cell type or tissue
0.7
microRNA
0.7
transcription factor
0.66


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.18   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.18   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
43.8
testosterone measurement
1
1
1
32.8
body fat distribution
2
1
4
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
43.8
testosterone measurement
1
32.8
body fat distribution
4
21
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 28 member 3
VGNC:8932
472969
Macaque
solute carrier family 28 member 3
709560
Mouse
MGI:2137361
114304
Rat
RGD:621224
140944
Cow
solute carrier family 28 member 3
VGNC:34793
508028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 28 member 3
Macaque
solute carrier family 28 member 3
Mouse
Rat
Cow
solute carrier family 28 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAS3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (54)
1 – 10 of 54
SLC29A1
Tclin
Family:  Transporter
Novelty:  0.002085
Score:  0.897
Data Source:  STRINGDB
SLC29A2
Tbio
Family:  Transporter
Novelty:  0.00801619
Score:  0.874
Data Source:  STRINGDB
SLC29A3
Tbio
Family:  Transporter
Novelty:  0.01133239
Score:  0.723
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.707
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.671
Data Source:  STRINGDB
CETN3
Tbio
Novelty:  0.00705513
Score:  0.618
Data Source:  STRINGDB
SLC29A4
Tchem
Family:  Transporter
Novelty:  0.00772914
Score:  0.613
Data Source:  STRINGDB
SLC35F5
Tdark
Family:  Transporter
Novelty:  0.53360993
Score:  0.574
Data Source:  STRINGDB
SLCO1B1
Tchem
Family:  Transporter
Novelty:  0.00126613
Score:  0.554
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.553
Data Source:  STRINGDB
Publication Statistics
PubMed Score  89.18

PubMed score by year
PubTator Score  66.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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