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Tbio
C17orf75
Protein Njmu-R1

Protein Summary
Description
As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000577809
  • ENSP00000464275
  • ENSG00000108666

Symbol
  • SRI2
  • NJMU-R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
55.8
chronotype measurement
1
1
1
17.8
1
1
0
1.1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
55.8
chronotype measurement
1
17.8
0
1.1
2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 17 C17orf75 homolog
VGNC:10098
454572
Macaque
chromosome 16 open reading frame, human C17orf75
714040
Mouse
MGI:1917841
70591
Rat
RGD:1310429
303764
Dog
chromosome 9 C17orf75 homolog
VGNC:51929
480612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 17 C17orf75 homolog
Macaque
chromosome 16 open reading frame, human C17orf75
Mouse
Rat
Dog
chromosome 9 C17orf75 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAS0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (42)
1 – 10 of 42
FAM91A1
Tbio
Novelty:  0.76982657
p_int:  0.999999996
p_ni:  4e-9
Score:  0.97
Data Source:  BioPlex,STRINGDB
WDR11
Tbio
Novelty:  0.00560058
p_int:  0.999992097
p_ni:  0.000007903
Score:  0.953
Data Source:  BioPlex,STRINGDB
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.999629571
p_ni:  0.000370429
Data Source:  BioPlex
DDHD1
Tbio
Family:  Enzyme
Novelty:  0.05209502
p_int:  0.999223852
p_ni:  0.000775549
p_wrong:  5.99e-7
Data Source:  BioPlex
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.993268655
p_ni:  0.006731345
Score:  0.362
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.992111543
p_ni:  0.007888457
Data Source:  BioPlex
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.988360049
p_ni:  0.011623903
p_wrong:  0.000016048
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.985691231
p_ni:  0.014308765
p_wrong:  3e-9
Data Source:  BioPlex
FAS
Tbio
Novelty:  0.00043286
p_int:  0.983957396
p_ni:  0.016042603
p_wrong:  1e-9
Score:  0.71
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.972131276
p_ni:  0.027868724
Data Source:  BioPlex
Publication Statistics
PubMed Score  9.61

PubMed score by year
PubTator Score  5.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer