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Tbio
ADGRL3
Adhesion G protein-coupled receptor L3

Protein Summary
Description
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512091
  • ENSP00000423388
  • ENSG00000150471
  • ENST00000514591
  • ENSP00000422533

Symbol
  • KIAA0768
  • LEC3
  • LPHN3
  • CL3
  • LEC3
  • CIRL3
  • LPHN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.97
PubMedID
0.75
transcription factor perturbation
0.74
gene perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.82   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.82   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (226)
1 – 10 of 226
FLRT1
Tdark
Novelty: 0.3774664
p_int: 0.999999966
p_ni: 3.2e-8
p_wrong: 2e-9
Score: 0.83
Data Source: BioPlex,STRINGDB
LPAR1
Tchem
Family: GPCR
Novelty: 0.004102
p_int: 0.999799842
p_ni: 0.000200147
p_wrong: 1e-8
Score: 0.176
Data Source: BioPlex,STRINGDB
TMEM9
Tbio
Novelty: 0.1192335
p_int: 0.959603557
p_ni: 0.032247809
p_wrong: 0.008148633
Data Source: BioPlex
ASGR2
Tbio
Novelty: 0.35502959
p_int: 0.955203172
p_ni: 0.000191358
p_wrong: 0.04460547
Score: 0.241
Data Source: BioPlex,STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00700844
p_int: 0.889368869
p_ni: 0.002886284
p_wrong: 0.107744847
Score: 0.163
Data Source: BioPlex,STRINGDB
MMP26
Tchem
Family: Enzyme
Novelty: 0.02416223
p_int: 0.837525416
p_ni: 0.00170654
p_wrong: 0.160768044
Score: 0.19
Data Source: BioPlex,STRINGDB
CLEC2D
Tbio
Novelty: 0.03470529
p_int: 0.834211865
p_ni: 0.000441152
p_wrong: 0.165346983
Score: 0.189
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.04063664
p_int: 0.829561783
p_ni: 0.001682824
p_wrong: 0.168755393
Data Source: BioPlex
FLRT3
Tbio
Novelty: 0.05184484
Score: 0.99
Data Source: STRINGDB
FLRT2
Tbio
Novelty: 0.09101483
Score: 0.871
Data Source: STRINGDB
Publication Statistics
PubMed Score  529.82

PubMed score by year
PubTator Score  98.51

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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