Tbio ADGRL3 Adhesion G protein-coupled receptor L3

Protein Summary

Description

Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HAR2
• E9PE04
• O94867
• Q9NWK5

Gene Name

• ADGRL3

Ensembl ID

• ENST00000512091
• ENSP00000423388
• ENSG00000150471
• ENST00000514591
• ENSP00000422533

Symbol

• KIAA0768
• LEC3
• LPHN3
• CL3
• LEC3
• CIRL3
• LPHN3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
trait	0.97
PubMedID	0.75
transcription factor perturbation	0.74
gene perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor L3

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor L3

Protein / ... / Protease / Adhesion G Protein-coupled Receptor L3

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Latrophilin Receptor / Latrophilin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.38   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.38   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0