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Tbio
ADGRL3
Adhesion G protein-coupled receptor L3

Protein Summary
Description
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512091
  • ENSP00000423388
  • ENSG00000150471
  • ENST00000514591
  • ENSP00000422533

Symbol
  • KIAA0768
  • LEC3
  • LPHN3
  • CL3
  • LEC3
  • CIRL3
  • LPHN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.97
PubMedID
0.75
transcription factor perturbation
0.74
gene perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.76   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.76   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (226)
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.999999966
p_ni:  3.2e-8
p_wrong:  2e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999799842
p_ni:  0.000200147
p_wrong:  1e-8
Score:  0.176
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.959603557
p_ni:  0.032247809
p_wrong:  0.008148633
Data Source:  BioPlex
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.955203172
p_ni:  0.000191358
p_wrong:  0.04460547
Score:  0.241
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.889368869
p_ni:  0.002886284
p_wrong:  0.107744847
Score:  0.163
Data Source:  BioPlex,STRINGDB
MMP26
Tchem
Family:  Enzyme
Novelty:  0.02180874
p_int:  0.837525416
p_ni:  0.00170654
p_wrong:  0.160768044
Score:  0.19
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.834211865
p_ni:  0.000441152
p_wrong:  0.165346983
Score:  0.189
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.829561783
p_ni:  0.001682824
p_wrong:  0.168755393
Data Source:  BioPlex
FLRT3
Tbio
Novelty:  0.05467656
Score:  0.99
Data Source:  STRINGDB
FLRT2
Tbio
Novelty:  0.08424771
Score:  0.871
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
10
75.6
1
1
0
14.3
73
self reported educational attainment
1
3
3
42
risk-taking behaviour
1
1
1
35
Ischemic stroke
1
1
0
14.3
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
10
75.6
0
14.3
73
self reported educational attainment
3
42
risk-taking behaviour
1
35
Ischemic stroke
0
14.3
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 380.76
PubMed score by year
PubTator Score 98.51
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title