You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LIN7B
Protein lin-7 homolog B

Protein Summary
Description
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221459
  • ENSP00000221459
  • ENSG00000104863
  • ENST00000391864
  • ENSP00000375737

Symbol
  • MALS2
  • VELI2
  • MALS2
  • VELI2
  • LIN-7B
  • MALS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
kinase perturbation
0.84
tissue sample
0.75
transcription factor perturbation
0.74
histone modification site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
67.7
testosterone measurement
2
2
2
50.5
body mass index
1
1
1
31.4
heel bone mineral density
1
1
1
31.4
electrocardiography
1
1
3
30.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
67.7
testosterone measurement
2
50.5
body mass index
1
31.4
heel bone mineral density
1
31.4
electrocardiography
3
30.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-7 homolog B, crumbs cell polarity complex component
VGNC:7789
747217
Macaque
lin-7 homolog B, crumbs cell polarity complex component
718587
Mouse
MGI:1330858
22342
Rat
RGD:620730
60377
Dog
lin-7 homolog B, crumbs cell polarity complex component
VGNC:53735
476417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-7 homolog B, crumbs cell polarity complex component
Macaque
lin-7 homolog B, crumbs cell polarity complex component
Mouse
Rat
Dog
lin-7 homolog B, crumbs cell polarity complex component
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HAP6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Dopamine Neurotransmitter Release Cycle
Neurexins and neuroligins
Neuronal System
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (86)
1 – 10 of 86
MPDZ
Tbio
Novelty:  0.01656439
p_int:  0.999999992
p_ni:  8e-9
Score:  0.293
Data Source:  BioPlex,STRINGDB
MPP7
Tbio
Novelty:  1.59072481
p_int:  0.999999985
p_ni:  1.4e-8
Score:  0.79
Data Source:  BioPlex,STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
p_int:  0.999999977
p_ni:  2.4e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
MPP2
Tbio
Novelty:  0.0372293
p_int:  0.999999961
p_ni:  1.3e-8
p_wrong:  2.7e-8
Score:  0.978
Data Source:  BioPlex,STRINGDB
PATJ
Tbio
Novelty:  0.01420008
p_int:  0.999999829
p_ni:  1.71e-7
Score:  0.47
Data Source:  BioPlex,STRINGDB
PXDC1
Tdark
Novelty:  0.82453616
p_int:  0.99999982
p_ni:  4.8e-8
p_wrong:  1.33e-7
Data Source:  BioPlex
MPP6
Tbio
Novelty:  0.08883057
p_int:  0.999999395
p_ni:  6.04e-7
p_wrong:  2e-9
Score:  0.893
Data Source:  BioPlex,STRINGDB
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.999998533
p_ni:  6.5e-8
p_wrong:  0.000001403
Score:  0.964
Data Source:  BioPlex,STRINGDB
APBA1
Tbio
Novelty:  0.01126648
p_int:  0.999998097
p_ni:  0.000001903
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
ARHGEF26
Tbio
Novelty:  0.09349583
p_int:  0.999995953
p_ni:  0.000004047
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.31

PubMed score by year
PubTator Score  6.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: